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Neutrophil‐to‐lymphocyte ratio for predicting palliative chemotherapy outcomes in advanced pancreatic cancer patients
- Source :
- Cancer Medicine
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- Several previous studies reported that the neutrophil-to-lymphocyte ratio (NLR) could be a promising prognostic factor for patients with cancer. We aimed to determine the prognostic value of NLR in patients with advanced pancreatic cancer (APC) following palliative chemotherapy. We retrospectively reviewed 252 consecutive APC patients receiving palliative chemotherapy between January 2006 and December 2012. We classified the patients according to the pretreatment NLR values (≤5 or >5) into two groups and investigated the difference in treatment outcomes, including time to treatment failure (TTF) and overall survival (OS). A total of 212 patients had pretreatment NLR values of ≤5 (group A), while 40 patients had an NLR of >5 (group B). TTF and OS were significantly shorter in group B than in group A (3.1 vs. 8.7 months and 6.0 vs. 12.8 months, respectively; both P 5. Our results support the idea that NLR can be a promising prognostic and predictive marker for APC patients receiving palliative chemotherapy.
- Subjects :
- Male
Oncology
Cancer Research
medicine.medical_specialty
Palliative care
Neutrophils
medicine.medical_treatment
pancreatic cancer
Deoxycytidine
NLR
Cohort Studies
Erlotinib Hydrochloride
Internal medicine
Pancreatic cancer
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Chemotherapy
Radiology, Nuclear Medicine and imaging
Lymphocytes
Prospective Studies
Neutrophil to lymphocyte ratio
prognostic factor
Prospective cohort study
Survival analysis
Aged
Tegafur
Original Research
Predictive marker
business.industry
Palliative Care
fungi
Cancer
Prognosis
medicine.disease
Survival Analysis
Gemcitabine
Surgery
Pancreatic Neoplasms
Drug Combinations
Oxonic Acid
Treatment Outcome
inflammation
Quinazolines
Female
business
Carcinoma, Pancreatic Ductal
Subjects
Details
- ISSN :
- 20457634
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Cancer Medicine
- Accession number :
- edsair.doi.dedup.....44595ac8c119de25cf9977bb5eca2f28