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Ki-ras mutations and prognosis in colorectal cancer
- Source :
- European journal of cancer (Oxford, England : 1990). 34(4)
- Publication Year :
- 1998
-
Abstract
- A total of 191 colorectal adenocarcinomas, obtained from consecutive patients with a median follow-up of 6 years, were studied in order to evaluate the possible association of Ki-ras mutations with tumour stage, tumour differentiation and survival time. Resected full-cross tumour samples were screened for Ki-ras mutations in codons 12 and 13 using temporal temperature gradient gel electrophoresis (TTGE). Ki-ras mutations were detected in 62 (32%) of the samples. The most frequent mutation, observed in 21 samples, was from GGT to GAT changing glycine to aspartic acid in codon 12. The study did not show any association between Ki-ras mutations and Dukes' stage or tumour differentiation. Patients with Ki-ras mutations had a marginally shorter survival time (median 50 months) compared with patients without (median 59 months), but the difference was not statistically significant. The results indicate that Ki-ras gene mutations have no relevant prognostic importance in this cohort of colorectal cancer patients.
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Pathology
Colorectal cancer
Rectum
Gene mutation
medicine.disease_cause
Gastroenterology
Cohort Studies
Internal medicine
medicine
Humans
Point Mutation
Stage (cooking)
Survival analysis
Aged
Neoplasm Staging
Aged, 80 and over
Mutation
business.industry
Middle Aged
medicine.disease
Prognosis
Survival Analysis
medicine.anatomical_structure
Cell Transformation, Neoplastic
Genes, ras
Oncology
Cohort
Adenocarcinoma
Female
business
Colorectal Neoplasms
Follow-Up Studies
Subjects
Details
- ISSN :
- 09598049
- Volume :
- 34
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- European journal of cancer (Oxford, England : 1990)
- Accession number :
- edsair.doi.dedup.....444ca40af8981dba89bcb15a0ff2be4b