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Urinary kallikrein excretion in type 1 (insulin-dependent) diabetes mellitus
- Source :
- Diabetologia. 36(5)
- Publication Year :
- 1993
-
Abstract
- Kidney haemodynamics appear to change after the early phases of diabetic nephropathy: increases in glomerular filtration rate and in renal plasma flow have been widely reported, while kidney size is increased. As the renal kallikrein-kinin system has been demonstrated to regulate kidney blood circulation, we have evaluated the excretion of urinary kallikrein in 87 Type 1 (insulin-dependent) diabetic patients with and without hyperfiltration. Urinary kallikrein excretion was measured in 24-h urine collections. The esterolytic activity was determined by fluorimetric assay. The excretion of urinary kallikreins was significantly higher in hyperfiltering patients (472 +/- 125 esterase units/24 h) than in normofiltering (168 +/- 77 esterase units/24 h) and control subjects (151 +/- 39 esterase units/24 h), p0.001. Furthermore, we observed a positive correlation between urinary kallikrein excretion and glomerular filtration rate (r = 0.785). These data suggest that variations of kallikrein and kinin concentrations may play a role in the alteration of renal haemodynamics in Type 1 diabetes. It is possible that the kinin-kallikrein system, the renin-angiotensin system and the prostaglandins may interact to determine the haemodynamic alterations which are present in the diabetic disease.
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Urinary system
Renal function
Blood Pressure
urologic and male genital diseases
Nephropathy
Blood Urea Nitrogen
Diabetic nephropathy
Reference Values
Internal medicine
Internal Medicine
medicine
Humans
Diabetic Nephropathies
cardiovascular diseases
Glycated Hemoglobin
Kidney
urogenital system
business.industry
Kallikrein
Kinin
medicine.disease
biological factors
medicine.anatomical_structure
Endocrinology
Diabetes Mellitus, Type 1
Renal blood flow
Creatinine
Female
Kallikreins
business
Biomarkers
circulatory and respiratory physiology
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 0012186X
- Volume :
- 36
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Diabetologia
- Accession number :
- edsair.doi.dedup.....442afe54a1983f8a1b2995a5dce53449