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CXCL12 as a biological marker for the diagnosis of tuberculous pleurisy
- Source :
- Tuberculosis. 92:248-252
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Although a chemokine CXCL12 is implicated in some infectious diseases, especially those in which T cell-mediated immunity plays critical roles, the relevance of CXCL12 to tuberculosis has never been elucidated. To determine the clinical efficacy of CXCL12 as a diagnostic marker for tuberculous (TB) pleurisy, we measured CXCL12 concentration in pleural fluid and serum from patients with various etiologies. Of 60 patients with pleural fluid, the median age of TB patients was 52 which was significantly lower than 71 of non-TB patients (P 0.01). CXCL12 level in TB effusion (4456 ± 1013 pg/mL, n = 15) was significantly higher than non-TB effusion (2851 ± 1229 pg/mL, n = 45) (P 0.01). On the other hand, serum CXCL12 level showed no significant differences among TB pleurisy, non-TB pleurisy, and normal healthy subjects. The sensitivity and specificity of CXCL12 in pleural fluid for the diagnosis of TB pleurisy was 60.0% and 93.2% (cut-off value = 4600 pg/mL), respectively. Area under the receiver operating characteristic (ROC) curve (AUC) for CXCL12 was 0.84. As the source of CXCL12, pleural mesothelium, endothelium of pulmonary vessels, bronchial epithelium, multinucleated giant epithelioid cells, and macrophages were positive for CXCL12 staining. Increased CXCL12 level in pleural fluid could be an informative diagnostic marker for differentiating TB pleurisy from other etiologies.
- Subjects :
- Adult
Microbiology (medical)
Pathology
medicine.medical_specialty
Chemokine
Tuberculosis
Immunology
Sensitivity and Specificity
Microbiology
CXCR4
Diagnosis, Differential
Interferon-gamma
Young Adult
Adenosine deaminase
Predictive Value of Tests
Immunity
Humans
Medicine
Pleurisy
Aged
Aged, 80 and over
biology
business.industry
Tuberculosis, Pleural
Middle Aged
medicine.disease
Chemokine CXCL12
biological factors
Pleural Effusion, Malignant
Pleural Effusion
Infectious Diseases
Effusion
Case-Control Studies
embryonic structures
Etiology
biology.protein
biological phenomena, cell phenomena, and immunity
business
Biomarkers
Subjects
Details
- ISSN :
- 14729792
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- Tuberculosis
- Accession number :
- edsair.doi.dedup.....4427f0af26b378583c5bb59788045432