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Extrafollicular Activation of Lymph Node B Cells by Antigen-Bearing Dendritic Cells
- Source :
- Science. 312:1672-1676
- Publication Year :
- 2006
- Publisher :
- American Association for the Advancement of Science (AAAS), 2006.
-
Abstract
- In contrast to naïve T cells that recognize short antigen-derived peptides displayed by specialized antigen-presenting cells, immunoglobulin receptors of B lymphocytes primarily recognize intact proteins. How and where within a lymph node such unprocessed antigens become available for naïve B cell recognition is not clear. We used two-photon intravital imaging to show that, after exiting high-endothelial venules and before entry into lymph node follicles, B cells survey locally concentrated dendritic cells. Engagement of the B cell receptor by the dendritic cell (DC)–associated antigen leads to lymphocyte calcium signaling, migration arrest, antigen acquisition, and extrafollicular accumulation. These findings suggest a possible role for antigen-specific B-DC interactions in promoting T cell–dependent antibody responses in vivo.
- Subjects :
- T-Lymphocytes
B-cell receptor
Antigen presentation
Naive B cell
Receptors, Antigen, B-Cell
Mice, Transgenic
Biology
Lymphocyte Activation
Mice
Cell Movement
Lymph node stromal cell
Animals
Calcium Signaling
Antigens
Antigen-presenting cell
Cell Shape
B-Lymphocytes
Multidisciplinary
Follicular dendritic cells
Dendritic Cells
Dendritic cell
Coculture Techniques
Endocytosis
Cell biology
Mice, Inbred C57BL
B-1 cell
Immunology
Calcium
Muramidase
Lymph Nodes
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 312
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....441f9372c87a1e01df5cc8a7f350fabb