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Expression of activated HER2 in human testes
- Source :
- Fertility and Sterility. 95:2725-2728
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- The her2 messenger RNA (mRNA) was the most abundant among the erb type-1 tyrosine kinase receptors mRNA in human testis and was statistically significantly decreased in impaired spermatogenesis. Testicular HER2 was tyrosine phosphorylated and strongly expressed in spermatogonia, early spermatocytes, elongating/elongated spermatids, Sertoli cells, Leydig cells, and peritubular cells, suggesting that activated HER2 participates in mitosis and meiotic entry of germ cells, spermiogenesis, and steroidogenesis via mediating the epidermal growth factor–growth factor signaling.
- Subjects :
- Adult
Male
endocrine system
medicine.medical_specialty
Receptor, ErbB-2
Spermiogenesis
Biopsy
Blotting, Western
Testicle
Receptor tyrosine kinase
Spermatocytes
Internal medicine
Republic of Korea
Testis
medicine
Humans
RNA, Messenger
Phosphorylation
Tyrosine
Spermatogenesis
skin and connective tissue diseases
Aged
Azoospermia
Messenger RNA
Sertoli Cells
biology
Reverse Transcriptase Polymerase Chain Reaction
urogenital system
Leydig Cells
Obstetrics and Gynecology
Middle Aged
Sertoli cell
Immunohistochemistry
Spermatids
Spermatogonia
Cell biology
medicine.anatomical_structure
Endocrinology
Reproductive Medicine
biology.protein
Subjects
Details
- ISSN :
- 00150282
- Volume :
- 95
- Database :
- OpenAIRE
- Journal :
- Fertility and Sterility
- Accession number :
- edsair.doi.dedup.....441c87d435393f4f34049acd0d7f3946