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Hypercalcemia in glucocorticoid withdrawal
- Source :
- Endocrinologia Japonica. 33:203-209
- Publication Year :
- 1986
- Publisher :
- Japan Endocrine Society, 1986.
-
Abstract
- We found severe hypercalcemia in the course of hydrocortisone withdrawal in a patient who had undergone unilateral adrenalectomy to resect a cortisolhypersecreting adenoma. Serum calcium gradually but progressively increased after unilateral adrenalectomy. Severe hypercalcemia developed on the 77th postoperative day (the 15th day after discontinuing hydrocortisone replacement). The serum concentration of calcium, PTH, 25 (OH) D, and 1, 25 (OH) 2D were 8.0mEq/1, less than 100pg/ml, 10.1ng/ml and 29.6pg/ml, respectively. This hypercalcemia was accompanied by marked urinary hydroxyproline excretion and less calcium excretion in the urine than the prevailing level of serum calcium. Serum concentrations of 25 (OH) D, 1, 25 (OH) 2D and PTH were not elevated during the severe hypercalcemia. We concluded that the hypercalcemia in this patient was due in part to enhanced bone resorption and increased renal tubular reabsorption of calcium as a result of glucocorticoid withdrawal, but not to the elevation of serum PTH or serum 25 (OH) D and serum 1, 25 (OH) 2D.
- Subjects :
- Adenoma
medicine.medical_specialty
medicine.medical_treatment
Urinary system
Adrenal Gland Neoplasms
chemistry.chemical_element
Urine
Calcium
Bone resorption
Excretion
Endocrinology
Internal medicine
medicine
Humans
Postoperative Period
Glucocorticoids
Hydrocortisone
Adrenalectomy
General Engineering
Middle Aged
Hydroxyproline
chemistry
Hypercalcemia
Female
hormones, hormone substitutes, and hormone antagonists
Glucocorticoid
medicine.drug
Subjects
Details
- ISSN :
- 21856370 and 00137219
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Endocrinologia Japonica
- Accession number :
- edsair.doi.dedup.....4413be486eb9c9d17f0d13a05b6e86e1