Back to Search
Start Over
Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats
- Source :
- Neurocritical care. 25(2)
- Publication Year :
- 2016
-
Abstract
- Cognitive dysfunction can be a long-term complication following subarachnoid hemorrhage (SAH). Preclinical models have been variously characterized to emulate this disorder. This study was designed to directly compare long-term cognitive deficits in the context of similar levels of insult severity in the cisterna magna double-blood (DB) injection versus prechiasmatic blood (PB) injection SAH models. Pilot work identified blood injectate volumes necessary to provide similar mortality rates (20–25 %). Rats were then randomly assigned to DB or PB insults. Saline injection and naive rats were used as controls. Functional and cognitive outcome was assessed over 35 days. DB and PB caused similar transient rotarod deficits. PB rats exhibited decreased anxiety behavior on the elevated plus maze, while anxiety was increased in DB. DB and PB caused differential deficits in the novel object recognition and novel object location tasks. Morris water maze performance was similarly altered in both models (decreased escape latency and increased swimming speed). SAH caused histologic damage in the medial prefrontal cortex, perirhinal cortex, and hippocampal CA1, although severity of injury in the respective regions differed between DB and PB. Both SAH models caused long-term cognitive deficits in the context of similar insult severity. Cognitive deficits differed between the two models, as did distribution of histologic injury. Each model offers unique properties and both models may be useful for study of SAH-induced cognitive deficits.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Elevated plus maze
Pathology
Subarachnoid hemorrhage
Morris water navigation task
Context (language use)
Critical Care and Intensive Care Medicine
Cisterna magna
03 medical and health sciences
0302 clinical medicine
Internal medicine
Perirhinal cortex
medicine
Animals
Cognitive Dysfunction
Rats, Wistar
Prefrontal cortex
Maze Learning
Behavior, Animal
business.industry
Neuropsychology
Subarachnoid Hemorrhage
medicine.disease
Rats
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
Cardiology
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15560961
- Volume :
- 25
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Neurocritical care
- Accession number :
- edsair.doi.dedup.....4403ce757d8bfe3e5121fbd0dff091c3