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Nodal Disease in Rectal Cancer Patients With Complete Tumor Response After Neoadjuvant Chemoradiation: Danger Below Calm Waters
- Source :
- Diseases of the colon and rectum. 60(12)
- Publication Year :
- 2017
-
Abstract
- A subset of patients with rectal cancer who undergo neoadjuvant chemoradiation therapy will develop a complete pathologic tumor response. Complete nodal response is not universal in these patients and is difficult to assess clinically. Quantifying the risk of nodal disease would allow for targeted therapy with either radical resection or "watchful waiting."This study aimed to identify risk factors for residual nodal disease in ypT0 rectal adenocarcinoma.This is a retrospective case control study.The National Cancer Database 2006 to 2014 was used to identify patients for this study.Patients with stage II/III rectal adenocarcinoma who completed chemoradiation therapy followed by resection and who had ypT0 tumors were included. Patients with metastatic disease and2 lymph nodes evaluated were excluded. Patients were divided into 2 groups: node positive and node negative.The main outcome was nodal disease. The secondary outcome was overall survival.A total of 42,257 patients with stage II/III rectal cancer underwent chemoradiation therapy and radical resection; 4170 (9.9%) patients had ypT0 tumors and 395 (9.5%) were node positive. Of patients with clinically node-negative disease (ie, pretreatment imaging), 6.2% were node positive after chemoradiation therapy and resection. In multivariable analysis, factors predictive of nodal disease included increasing (pretreatment) clinical N-stage, high tumor grade (3/4), perineural invasion, and lymphovascular invasion. Higher clinical T-stage was inversely associated with residual nodal disease. Overall 5-year survival was significantly different between patients with ypN0, ypN1, and ypN2 disease (87.4%, 82.2%, and 62.5%, p = 0.002).This study was limited by the lack of clinical detail in the database and the inability to assess recurrence.Ten percent of patients with ypT0 tumors had positive nodes after chemoradiation therapy and resection. Factors associated with residual nodal disease included clinical nodal disease at diagnosis and poor histologic features. Patients with any of these features should consider radical resection regardless of tumor response. Others could be suitable for "watchful waiting" strategies. See Video Abstract at http://links.lww.com/DCR/A458.
- Subjects :
- Male
medicine.medical_specialty
Pathology
Neoplasm, Residual
Colorectal cancer
medicine.medical_treatment
Adenocarcinoma
03 medical and health sciences
0302 clinical medicine
Risk Factors
medicine
Combined Modality Therapy
Humans
Neoplasm Invasiveness
Survival rate
Neoadjuvant therapy
Neoplasm Staging
Retrospective Studies
business.industry
Rectal Neoplasms
Gastroenterology
Retrospective cohort study
General Medicine
Chemoradiotherapy
Middle Aged
medicine.disease
Neoadjuvant Therapy
United States
Survival Rate
Treatment Outcome
030220 oncology & carcinogenesis
Case-Control Studies
Lymphatic Metastasis
030211 gastroenterology & hepatology
Female
Radiology
business
Watchful waiting
Subjects
Details
- ISSN :
- 15300358
- Volume :
- 60
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Diseases of the colon and rectum
- Accession number :
- edsair.doi.dedup.....43ff4bc09b32fdd2a21f79c31255a496