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Incomplete synthesis of the Sda/Cad blood group carbohydrate in gastrointestinal cancer
- Source :
- Biochimica et Biophysica Acta (BBA) - General Subjects. 1780:467-471
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Cancer-associated changes in cell surface carbohydrates, including incomplete synthesis of normal carbohydrate epitopes, strongly affect malignant and metastatic potential. Here, we report that compensating for the cancer-associated loss of a single glycosyltransferase, β1,4 N -acetylgalactosaminyltransferese T2, dramatically decreased cell surface expression of both E-selectin ligands (sialyl Lewis x and sialyl Lewis a ). This modification was associated with elevated expression of the Sd a carbohydrate determinant, which is expressed in normal gastrointestinal mucosa and is strikingly downregulated in cancer tissues. Loss of E-selectin ligands resulted in decreased adhesion of cancer cells to activated human endothelial cells in vitro and eventually suppressed metastatic potential in vivo .
- Subjects :
- Cell
Biophysics
Mice, Nude
Biology
Ligands
Biochemistry
Gene Expression Regulation, Enzymologic
Epitope
Substrate Specificity
Mice
chemistry.chemical_compound
Lewis Blood Group Antigens
Parietal Cells, Gastric
Glycosyltransferase
medicine
Animals
Humans
RNA, Messenger
Gastrointestinal cancer
Neoplasm Metastasis
Molecular Biology
Gastrointestinal Neoplasms
Cancer
Sialyl-Lewis A
medicine.disease
Gene Expression Regulation, Neoplastic
medicine.anatomical_structure
Sialyl-Lewis X
chemistry
Cancer cell
Blood Group Antigens
biology.protein
Cancer research
N-Acetylgalactosaminyltransferases
Glycolipids
E-Selectin
Subjects
Details
- ISSN :
- 03044165
- Volume :
- 1780
- Database :
- OpenAIRE
- Journal :
- Biochimica et Biophysica Acta (BBA) - General Subjects
- Accession number :
- edsair.doi.dedup.....43f17e808c6d8aabbf3854e00274a80d