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Modeling Fluid Resuscitation by Formulating Infusion Rate and Urine Output in Severe Thermal Burn Adult Patients: A Retrospective Cohort Study
- Source :
- BioMed Research International, Vol 2015 (2015), BioMed Research International
- Publication Year :
- 2015
- Publisher :
- Hindawi Limited, 2015.
-
Abstract
- Acute burn injuries are among the most devastating forms of trauma and lead to significant morbidity and mortality. Appropriate fluid resuscitation after severe burn, specifically during the first 48 hours following injury, is considered as the single most important therapeutic intervention in burn treatment. Although many formulas have been developed to estimate the required fluid amount in severe burn patients, many lines of evidence showed that patients still receive far more fluid than formulas recommend. Overresuscitation, which is known as “fluid creep,” has emerged as one of the most important problems during the initial period of burn care. If fluid titration can be personalized and automated during the resuscitation phase, more efficient burn care and outcome will be anticipated. In the present study, a dynamic urine output based infusion rate prediction model was developed and validated during the initial 48 hours in severe thermal burn adult patients. The experimental results demonstrated that the developed dynamic fluid resuscitation model might significantly reduce the total fluid volume by accurately predicting hourly urine output and has the potential to aid fluid administration in severe burn patients.
- Subjects :
- Adult
Male
Resuscitation
Fluid administration
medicine.medical_specialty
Article Subject
Adolescent
lcsh:Medicine
Blood Pressure
General Biochemistry, Genetics and Molecular Biology
Medicine
Humans
Intensive care medicine
Urine output
General Immunology and Microbiology
Adult patients
business.industry
lcsh:R
Burn treatment
Retrospective cohort study
General Medicine
Middle Aged
Thermal burn
Blood pressure
Emergency medicine
Fluid Therapy
Female
business
Burns
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 23146141 and 23146133
- Volume :
- 2015
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....43e56f1b78ca7e304fa4c1d23e982aa3