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Cerebral Microbleeds
- Source :
- Stroke. 35:1831-1835
- Publication Year :
- 2004
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2004.
-
Abstract
- Background and Purpose— Cerebral microbleeds (CMBs) are areas of low signal intensity on gradient echo T2*-weighted magnetic resonance imaging (T2*MRI) corresponding to hemosiderin deposits in the perivascular space. Microangiopathy from atherosclerosis or amyloid angiopathy might lead to the formation of these lesions; therefore, there may be associations between CMBs and cardiovascular risk factors, APOE allele status, and brain morphology. We examined these relationships in the Framingham Study (FHS). Methods— In 472 subjects from the FHS Offspring and Cohort, we related CMB status to age, sex, systolic blood pressure, total cholesterol and high-density lipoprotein cholesterol (HDL-C) levels, smoking, diabetes, total hemispheric brain volume, white matter hyperintensity volume (WMHV), and APOE allele status. Results— Overall prevalence of CMBs was 4.7%, but CMBs were more prevalent with advanced age and male sex. Blood pressure, brain volume, and WMHV were related to CMBs in crude analysis but not after adjustment for age and sex. There were no significant relationships demonstrated between CMBs and APOE allele status, cholesterol, smoking, or diabetes. Conclusions— There is a low prevalence of CMBs in the community and a strong relationship with increasing age and male sex. We found no independent relationships with cardiovascular risk factors, APOE status, brain volumes, or WMH.
- Subjects :
- Male
Apolipoprotein E
medicine.medical_specialty
Pathology
Blood Pressure
Angiopathy
Apolipoproteins E
Sex Factors
Framingham Heart Study
Risk Factors
Internal medicine
Diabetes mellitus
Humans
Medicine
Risk factor
Stroke
Aged
Advanced and Specialized Nursing
business.industry
Microcirculation
Microangiopathy
Brain morphometry
Age Factors
Brain
Middle Aged
medicine.disease
Lipids
Magnetic Resonance Imaging
Cardiovascular Diseases
Cerebrovascular Circulation
Cardiology
Female
Neurology (clinical)
Cardiology and Cardiovascular Medicine
business
Intracranial Hemorrhages
Subjects
Details
- ISSN :
- 15244628 and 00392499
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Stroke
- Accession number :
- edsair.doi.dedup.....43df703d95f8fd47eec777bbaaa47a85