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Thymosin-β4, and Human Vitronectin peptides Grafted to Collagen Tune Adhesion or VEGF Gene Expression in Human Cell Lines**
- Publication Year :
- 2021
- Publisher :
- Wiley-VCH Verlag GmbH & Co. KGaA, 2021.
-
Abstract
- In order to improve collagen bioactivity for regenerative medicine approaches, thymosin-β4 (Tβ4P) and Human Vitronectin (HVP) derived peptides are grafted to collagen by thiol-ene Michael addition. Tβ4P and HVP are known to exert a pro-angiogenic and a pro-adhesive activity respectively and HVP is involved in osteogenesis promotion. The ability of these peptides to increase collagen cell adhesion and angiogenesis properties is assessed on human cell lines. In particular, HVP-grafted collagen increased human osteoblast adhesion and cell proliferation: after 24 h, both adhesion and proliferation roughly showed a 4-fold increase, if compared to pristine collagen. Tβ4P-grafted collagen promotes Vascular Endothelial Growth Factor (VEGF) gene expression in human vascular cell lines by more than 7 times. These results suggest that HVP-grafted collagen may be an interesting biomaterial for bone tissue regeneration, while Tβ4P-grafted collagen is useful for angiogenesis promotion.
- Subjects :
- collagen
human dermal lymphatic endothelial cells
human dermal lymphatic endothelial cell
VEGF receptors
medicine.medical_treatment
human osteoblast
Gene expression
CHIM/06 - CHIMICA ORGANICA
medicine
human osteoblasts
Thymosin β4
biology
Chemistry
covalent grafting
growth factor
human vitronectin
peptides
thymosin-beta 4
thymosin-β4
Growth factor
General Chemistry
Adhesion
Human cell
peptide
Cell biology
biology.protein
Vitronectin
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....43d6741b951e4c25652c046fa60d0e6b