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Morphological features and mucin expression profile of breast carcinomas with signet-ring cell differentiation
- Source :
- Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP
- Publication Year :
- 2014
-
Abstract
- Signet-ring cells are relatively common in breast cancers but are frequently overlooked. Although previously defined as a subtype of mucin producing carcinomas, breast carcinomas with signet-ring cell (SRC) differentiation nowadays are not considered a distinct entity.The objective of the present study was to characterize the morphological features and mucin expression profile of breast carcinomas with SRC differentiation. All breast carcinomas diagnosed at Centro Hospitalar S. Joao between 1996 and 2006 in which the pathology report mentioned the presence of SRCs (n= 11) and four mucinous carcinomas were included in the study. The frequency of SRCs and immunohistochemistry expression of MUC1/MUC2/MUC5AC/MUC6 were evaluated.We confirmed that SRC differentiation can occur in different histological types, including ductal, lobular, mucinous and metaplastic carcinomas. The proportion of SRCs was highly variable (range: 8-70%). Tumors encompassed SRCs of intracytoplasmic lumina and goblet-cell type. A higher percentage of SRCs was associated with lymphovascular invasion (p= 0.047). All tumors expressed cytoplasmic and membranous MUC1. Secretory mucins were more frequent in mucinous carcinomas and in carcinomas with extensive SRC differentiation.We conclude that besides the usefulness of mucin immunodetection for the differential diagnosis of carcinomas with SRC differentiation of breast origin, it is important to report SRC differentiation regardless of histological type because of its intrinsic prognostic value. We especially thank Professor Sobrinho-Simões for the careful review of the manuscript. IPATIMUP integrates the i3S Research Unit, which is partially supported by FCT, the Portuguese Foundation for Science and Technology. This work is funded by FEDER funds through the Operational Program for Competitiveness Factors-COMPETE and National Funds through the FCT-Foundation for Science and Technology , under the projects: PEst-C/SAU/LA0003/2013 and PTDC/BBB-EBI/0786/2012 .
- Subjects :
- Adult
Pathology
medicine.medical_specialty
Breast Neoplasms/pathology
Lymphovascular invasion
Breast Neoplasms
Biology
Stomach Neoplasms/metabolism
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Stomach Neoplasms
Carcinoma, Signet Ring Cell/metabolism
Immunohistochemistry/methods
medicine
Biomarkers, Tumor
Cell Differentiation/physiology
Humans
skin and connective tissue diseases
Cell Shape
MUC1
030304 developmental biology
Aged
Aged, 80 and over
0303 health sciences
Membrane Glycoproteins
Signet ring cell
Stomach Neoplasms/pathology
Mucin
Membrane Glycoproteins/metabolism
Mucins
Cell Differentiation
Cell Biology
Middle Aged
Immunohistochemistry
3. Good health
Mucins/metabolism
Breast Neoplasms/metabolism
Biomarkers, Tumor/metabolism
030220 oncology & carcinogenesis
Female
Differential diagnosis
Breast carcinoma
Carcinoma, Signet Ring Cell
Proto-oncogene tyrosine-protein kinase Src
Subjects
Details
- ISSN :
- 16180631
- Volume :
- 211
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Pathology, research and practice
- Accession number :
- edsair.doi.dedup.....43cdb99c57c65f1351baf6c270b0be7a