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The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors
- Source :
- Hauge, S C, Jensen, C K, Nielsen, L K, Pedersen, O B, Sørensen, E, Thørner, L W, Hjalgrim, H, Erikstrup, C, Nielsen, K R, Kaspersen, K A, Didriksen, M, Dziegiel, M & Ullum, H 2018, ' The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors ', APMIS Supplementum, vol. 126, no. 3, pp. 248-256 . https://doi.org/10.1111/apm.12807, Hauge, S C, Jensen, C K, Nielsen, L K, Pedersen, O B, Sørensen, E, Thørner, L W, Hjalgrim, H, Erikstrup, C, Nielsen, K R, Kaspersen, K A, Didriksen, M, Dziegiel, M & Ullum, H 2018, ' The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors ', A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, vol. 126, no. 3, pp. 248-256 . https://doi.org/10.1111/apm.12807, Hauge, S C, Jensen, C K, Nielsen, L K, Pedersen, O B, Sørensen, E, Thørner, L W, Hjalgrim, H, Erikstrup, C, Nielsen, K R, Kaspersen, K A, Didriksen, M, Dziegiel, M & Ullum, H 2018, ' The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors ', APMIS-Journal of Pathology, Microbiology and Immunology, vol. 126, no. 3, pp. 248-256 . https://doi.org/10.1111/apm.12807
- Publication Year :
- 2018
-
Abstract
- The clinical importance of immunoglobulin A (IgA) deficiency in otherwise healthy individuals is not well described. We aimed to investigate the self-reported mental and physical health and the risk of infection in IgA-deficient blood donors compared to healthy control blood donors. Infectious events, recorded in public health registries either as prescriptions filled of any antimicrobial medicine or as hospital infections, were compared between 177 IgA-deficient blood donors and 1770 control blood donors. A subset of the IgA-deficient donors were further characterized by self-reported health (Short Form-12, n = 28) and circulating C-reactive protein (CRP) (n = 10). IgA-deficient individuals had lower self-reported mental health (p = 0.01) and higher CRP (p < 0.05). A strong trend was found regarding prescription of antimicrobial medicine (hazard ratio = 1.19, p = 0.05). No association was found with hospital infections (hazard ratio = 1.02, p = 0.95) or self-reported physical health (p = 0.86). IgA-deficient blood donors have impaired self-reported mental health, enhanced inflammation and possibly an increased risk of infection. Despite these findings, this study does not provide sufficient evidence to warrant specific health precautions for donors with IgA deficiency.
- Subjects :
- Microbiology (medical)
Immunoglobulin A
Adult
Male
Risk
medicine.medical_specialty
Denmark
Inflammation
Blood Donors
030204 cardiovascular system & hematology
Infections
Pathology and Forensic Medicine
C-reactive protein
03 medical and health sciences
Diagnostic Self Evaluation
Young Adult
0302 clinical medicine
Quality of life
Internal medicine
Surveys and Questionnaires
Immunology and Allergy
Medicine
Humans
Genetic Predisposition to Disease
030212 general & internal medicine
Medical prescription
Infection/epidemiology
biology
business.industry
Public health
C-Reactive Protein/metabolism
Hazard ratio
IgA Deficiency
General Medicine
Middle Aged
Mental health
infection
Denmark/epidemiology
IgA Deficiency/genetics
C-Reactive Protein
quality of life
Immunoglobulin A/genetics
biology.protein
IgA deficiency
Female
medicine.symptom
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Hauge, S C, Jensen, C K, Nielsen, L K, Pedersen, O B, Sørensen, E, Thørner, L W, Hjalgrim, H, Erikstrup, C, Nielsen, K R, Kaspersen, K A, Didriksen, M, Dziegiel, M & Ullum, H 2018, ' The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors ', APMIS Supplementum, vol. 126, no. 3, pp. 248-256 . https://doi.org/10.1111/apm.12807, Hauge, S C, Jensen, C K, Nielsen, L K, Pedersen, O B, Sørensen, E, Thørner, L W, Hjalgrim, H, Erikstrup, C, Nielsen, K R, Kaspersen, K A, Didriksen, M, Dziegiel, M & Ullum, H 2018, ' The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors ', A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, vol. 126, no. 3, pp. 248-256 . https://doi.org/10.1111/apm.12807, Hauge, S C, Jensen, C K, Nielsen, L K, Pedersen, O B, Sørensen, E, Thørner, L W, Hjalgrim, H, Erikstrup, C, Nielsen, K R, Kaspersen, K A, Didriksen, M, Dziegiel, M & Ullum, H 2018, ' The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors ', APMIS-Journal of Pathology, Microbiology and Immunology, vol. 126, no. 3, pp. 248-256 . https://doi.org/10.1111/apm.12807
- Accession number :
- edsair.doi.dedup.....43c5fc3da70c014514bb8ecdbc6a8a6a