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Synthesis and Characterization of FITC Labelled Ruthenium Dendrimer as a Prospective Anticancer Drug
Synthesis and Characterization of FITC Labelled Ruthenium Dendrimer as a Prospective Anticancer Drug
- Source :
- Biomolecules, Volume 9, Issue 9, Biomolecules, Vol 9, Iss 9, p 411 (2019)
- Publication Year :
- 2019
- Publisher :
- MDPI, 2019.
-
Abstract
- Metallodendrimers&mdash<br />dendrimers with included metals&mdash<br />are widely investigated as biocompatible equivalents to metal nanoparticles. Applications can be expected in the fields of catalysis, as chemical sensors in molecular recognition and as anticancer drugs. Metallodendrimers can also mimic certain biomolecules, for example, haemoprotein in the case of using a dendrimer with a porphyrin core. In previous papers, we showed the promising anticancer effects of carbosilane ruthenium dendrimers. The present paper is devoted to studying biocompatibility and the cytotoxic effect on normal and cancer cells of carbosilane ruthenium dendrimers labelled with fluorescent probe fluorescein isothiocyanate (FITC). The addition of fluorescent probe allowed tracking the metallodendrimer in both normal and cancer cells. It was found that carbosilane ruthenium dendrimer labelled with FITC in concentration up to 10 &micro<br />mol/L was more cytotoxic for cancer cells than for normal cells. Thus, FITC labelled carbosilane ruthenium dendrimer is a good candidate for diagnostic imaging and studying anticancer effects of metallodendrimers in cancer therapy.
- Subjects :
- Dendrimers
Erythrocytes
Biocompatibility
anticancer therapeutic agent
Cell Survival
lcsh:QR1-502
chemistry.chemical_element
Antineoplastic Agents
02 engineering and technology
010402 general chemistry
01 natural sciences
Biochemistry
Hemolysis
lcsh:Microbiology
Article
Ruthenium
Cell Line
chemistry.chemical_compound
Molecular recognition
Dendrimer
ruthenium dendrimer
Humans
Particle Size
Fluorescein isothiocyanate
Molecular Biology
Drug Carriers
FITC labelled dendrimer
controlled polymer carrier
Metallodendrimer
021001 nanoscience & nanotechnology
Porphyrin
Combinatorial chemistry
0104 chemical sciences
3. Good health
chemistry
Cancer cell
0210 nano-technology
Fluorescein-5-isothiocyanate
Subjects
Details
- Language :
- English
- ISSN :
- 2218273X
- Volume :
- 9
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Biomolecules
- Accession number :
- edsair.doi.dedup.....43b0e237851009054cb958adda56912f