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Bladder preservation: Translating discovery for clinical impact in urothelial cancer
- Source :
- Urol Oncol
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Muscle-invasive bladder cancer can be treated with either radical cystectomy or bladder preservation approaches, and there is a need for reliable biomarkers to guide the optimal choice of therapy. The recent elucidation of the genomic landscape and biological drivers of bladder cancer has enabled the identification of tumor molecular features that may be helpful in driving clinical decision-making. Here, we summarize recent efforts to develop molecular biomarkers that could be leveraged to guide therapeutic decisions, post-treatment monitoring, and the optimal use of bladder preservation approaches for the effective treatment of muscle-invasive bladder cancer.
- Subjects :
- Oncology
medicine.medical_specialty
Urology
medicine.medical_treatment
030232 urology & nephrology
urologic and male genital diseases
Article
Bladder preservation
Cystectomy
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Urothelial cancer
Effective treatment
Carcinoma, Transitional Cell
Bladder cancer
business.industry
medicine.disease
Molecular biomarkers
female genital diseases and pregnancy complications
Urinary Bladder Neoplasms
030220 oncology & carcinogenesis
Identification (biology)
business
Organ Sparing Treatments
Subjects
Details
- ISSN :
- 10781439
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Urologic Oncology: Seminars and Original Investigations
- Accession number :
- edsair.doi.dedup.....43a670db57eb5fa1e606689e83a714a5