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Anti-obesity and fatty liver-preventing activities of Lonicera�caerulea in high-fat diet-fed mice
- Source :
- International Journal of Molecular Medicine
- Publication Year :
- 2018
- Publisher :
- Spandidos Publications, 2018.
-
Abstract
- Blue honeysuckle (BH, Lonicera caerulea) is used as a traditional medicine in Russia, Japan and China, but is not commonly considered as an edible berry in Europe, USA or Korea. BH has been revealed to decrease serum cholesterol and triacylglycerol (triglyceride or TG) levels through the activation of AMP-activated protein kinase (AMPK), thus it is expected to be a health functional food and pharmaceutical agent for the prevention of non-alcoholic liver damage, in addition to effects as a suppressor of hyperlipidemia and as an anti-obesity agent. In the present study, the pharmacological activity of BH extract (BHe) was observed in high-fat diet (HFD)-fed mice. Significant increases in fat pad weight, body weight, fat accumulation (body and abdominal fat density, and thickness of the periovarian and abdominal wall) and serum biochemical levels (aspartate transaminase, alanine amino-transferase, alkaline phosphatase, lactate dehydrogenase, γ-glutamyltransferase, total cholesterol, low-density lipoprotein and TG, with the exception of high-density lipoprotein) were observed in HFD-fed mice. In addition, increases in adipocyte hypertrophy, the area of steatohepatitis and hepatocyte hypertrophy were observed, whereas decreased zymogen content was identified upon histopathological observation. Increased deterioration of the endogenous antioxidant defense system (liver catalase, glutathione and superoxide dismutase) and hepatic lipid peroxidation was observed. In addition, there were decreases in hepatic glucokinase activity, AMPKα1 and AMPKα2 mRNA expression, adipose tissue uncoupling protein 2 expression, and adiponectin mRNA expression, increases in phosphoenolpyruvate carboxykinase and glucose-6-phosphatase activity, hepatic acetyl-CoA carboxylase 1 mRNA expression, and the expression of leptin, CCAAT/enhancer-binding protein (C/EBP) α, C/EBPβ and sterol-regulatory-element-binding protein 1c mRNA in the periovarian tissue. Furthermore, non-alcoholic fatty liver disease (NAFLD) and obesity were significantly inhibited by the continuous administration of BHe for 84 days. These results revealed that BHe may be a promising novel drug or functional food candidate for the treatment of obesity and NAFLD.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
mice
Adipose tissue
Aspartate transaminase
Diet, High-Fat
Fat pad
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Genetics
medicine
Lonicera caerulea
Animals
Adiponectin
biology
Triglyceride
Plant Extracts
Chemistry
Fatty liver
Articles
Organ Size
General Medicine
Lipid Metabolism
medicine.disease
Lipids
blue honeysuckle
Fatty Liver
Lonicera
030104 developmental biology
Endocrinology
Adipose Tissue
Gene Expression Regulation
Liver
Hepatocytes
biology.protein
anti-obesity effect
Female
Anti-Obesity Agents
Lipid Peroxidation
Steatohepatitis
Biomarkers
030217 neurology & neurosurgery
Lipoprotein
Subjects
Details
- ISSN :
- 1791244X and 11073756
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Medicine
- Accession number :
- edsair.doi.dedup.....43a1b23ae3c766eb69b78181c0cec65c