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Kappa free light chain index as a diagnostic biomarker in multiple sclerosis: A real-world investigation
- Source :
- Journal of neurochemistryREFERENCES. 159(3)
- Publication Year :
- 2021
-
Abstract
- Kappa free light chain (KFLC) index, a measure for intrathecal production of free kappa chains, has been increasingly recognized for its diagnostic potential in multiple sclerosis (MS) as a quantitative alternative to IgG oligoclonal bands (OCBs). Our objective was to investigate the sensitivity, specificity, and overall diagnostic accuracy of KFLC index in MS. KFLC index was prospectively determined as part of the diagnostic workup in patients with suspected MS (n = 327) between May 2013 and February 2020. Patients with clinically isolated syndrome (CIS), radiologically isolated syndrome (RIS), and MS had markedly higher KFLC index (44.6, IQR 16-128) compared with subjects with other neuro-inflammatory disorders (ONID) and symptomatic controls (SC) (2.19, IQR 1.68-2.98, p
- Subjects :
- Adult
Male
medicine.medical_specialty
Index (economics)
Multiple Sclerosis
Biochemistry
Gastroenterology
Sensitivity and Specificity
Diagnosis, Differential
Cellular and Molecular Neuroscience
Cerebrospinal fluid
Internal medicine
medicine
Diagnostic biomarker
Humans
Inflammation
Clinically isolated syndrome
business.industry
Multiple sclerosis
Reproducibility of Results
medicine.disease
Free Light Chain
Magnetic Resonance Imaging
Spinal Cord
Immunoglobulin G
Disease Progression
Female
Immunoglobulin Light Chains
Igg index
business
Kappa
Biomarkers
Demyelinating Diseases
Subjects
Details
- ISSN :
- 14714159
- Volume :
- 159
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of neurochemistryREFERENCES
- Accession number :
- edsair.doi.dedup.....43a0ae7620fc1da9c5481e2e1e8b6349