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Interactions among moderate/severe periodontitis, ADIPOQ-rs1501299, and LEPR-rs1137100 polymorphisms on the risk of type 2 diabetes in a Chinese population
- Source :
- Archives of oral biology. 103
- Publication Year :
- 2019
-
Abstract
- Objective Type 2 diabetes mellitus (T2DM) is a complex disease influenced by genes and the environment. Periodontitis a demonstrated risk factor of T2DM. Previous studies related to gene-environment interactions on the risk of T2DM mainly focused on gene-obesity interactions. However, the impact of gene-periodontitis interaction on the risk of T2DM has not yet been investigated. This study aimed to investigate gene-environment interactions among moderate/severe periodontitis, polymorphisms of adiponectin (ADIPOQ)-rs1501299, and leptin receptor (LEPR)-rs1137100 on T2DM risk in Chinese subjects. Design A case-control study was conducted in 239 Chinese participants from Beijing Hypertension Association Institute (BHAL). After full-mouth periodontal examinations, the participants underwent bilateral buccal swabs for DNA testing. ADIPOQ-rs1501299 and LEPR-rs1137100 were used for genotyping. Generalised multifactor dimensionality reduction (GMDR) and logistic regression were used to examine the interactions among single nucleotide polymorphisms (SNPs) and moderate/severe periodontitis on the risk of T2DM. Results The risk of T2DM was higher in moderate/severe periodontitis [adjusted odds ratio (AOR) = 3.67, 95% confidence interval (95%CI): 1.26–10.71] in ADIPOQ-rs1501299 GG genotype (AOR = 3.42, 95%CI: 1.81–6.46) and LEPR-rs1137100 GG genotype (AOR = 3.16, 95%CI: 1.56–6.39). The GMDR model indicated that there was a significant three-factor model (p = 0.001) involving rs1501299, rs1137100, and moderate/severe periodontitis, demonstrating a potential gene-environment interaction among periodontitis, polymorphisms of rs1501299, and rs1137100 influencing the risk of T2DM. Moderate/severe periodontitis patients with rs1501299-GG and rs1137100-GG have the highest T2DM risk after adjusting for age, gender, BMI, WHR, smoking status, alcohol consumption, economic status, and hypertension (AOR = 20.39, 95%CI: 2.64–157.26). Conclusions Interactions among moderate/severe periodontitis, rs1501299-GG, and rs1137100-GG were associated with an increased risk of T2DM. This study may provide a new insight into the effect of gene-environment interactions on T2DM.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
endocrine system diseases
Genotype
Single-nucleotide polymorphism
Type 2 diabetes
Severe periodontitis
Polymorphism, Single Nucleotide
03 medical and health sciences
0302 clinical medicine
Asian People
Risk Factors
Internal medicine
Medicine
Humans
Genetic Predisposition to Disease
Periodontitis
General Dentistry
Multifactor dimensionality reduction
Adiponectin
business.industry
nutritional and metabolic diseases
Type 2 Diabetes Mellitus
030206 dentistry
Cell Biology
General Medicine
Odds ratio
medicine.disease
030104 developmental biology
Otorhinolaryngology
Diabetes Mellitus, Type 2
Case-Control Studies
Receptors, Leptin
Gene-Environment Interaction
business
Subjects
Details
- ISSN :
- 18791506
- Volume :
- 103
- Database :
- OpenAIRE
- Journal :
- Archives of oral biology
- Accession number :
- edsair.doi.dedup.....439394df81d3a546e4be38631865a339