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Clinical Genomics for the Diagnosis of Monogenic Forms of Inflammatory Bowel Disease: A Position Paper From the Paediatric IBD Porto Group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition
- Source :
- J Pediatr Gastroenterol Nutr, Journal of pediatric gastroenterology and nutrition, 72(3), 456-473. Lippincott Williams and Wilkins, Journal of Pediatric Gastroenterology and Nutrition, 72(3), 456-473. Lippincott Williams & Wilkins
- Publication Year :
- 2021
-
Abstract
- BACKGROUND: It is important to identify patients with monogenic IBD as management may differ from classical IBD. In this position statement we formulate recommendations for the use of genomics in evaluating potential monogenic causes of IBD across age groups. METHODS: The consensus included paediatric IBD specialists from the Paediatric IBD Porto group of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and specialists from several monogenic IBD research consortia. We defined key topics and performed a systematic literature review to cover indications, technologies (targeted panel, exome and genome sequencing), gene panel setup, cost-effectiveness of genetic screening, and requirements for the clinical care setting. We developed recommendations that were voted upon by all authors and Porto group members (32 voting specialists). RESULTS: We recommend next-generation DNA-sequencing technologies to diagnose monogenic causes of IBD in routine clinical practice embedded in a setting of multidisciplinary patient care. Routine genetic screening is not recommended for all IBD patients. Genetic testing should be considered depending on age of IBD-onset (infantile IBD, very early-onset IBD, paediatric or young adult IBD), and further criteria, such as family history, relevant comorbidities, and extraintestinal manifestations. Genetic testing is also recommended in advance of hematopoietic stem cell transplantation. We developed a diagnostic algorithm that includes a gene panel of 75 monogenic IBD genes. Considerations are provided also for low resource countries. CONCLUSIONS: Genomic technologies should be considered an integral part of patient care to investigate patients at risk for monogenic forms of IBD.
- Subjects :
- medicine.medical_specialty
very early-onset inflammatory bowel disease
MEDLINE
primary immunodeficiency
digestive system
Article
ulcerative coliti
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
Internal medicine
Medicine
Humans
Family history
Young adult
Intensive care medicine
Child
Exome
Genetic testing
medicine.diagnostic_test
business.industry
Gastroenterology
Genomics
Hepatology
Colitis
Inflammatory Bowel Diseases
digestive system diseases
Crohn's disease
Systematic review
Pediatrics, Perinatology and Child Health
Genomic
Position paper
030211 gastroenterology & hepatology
genetic
business
Child Nutritional Physiological Phenomena
exome sequencing
Coliti
Human
Subjects
Details
- Language :
- English
- ISSN :
- 02772116
- Volume :
- 72
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of pediatric gastroenterology and nutrition
- Accession number :
- edsair.doi.dedup.....4360c3e1537d606b60b0b004822da505