Back to Search
Start Over
Ectodomain shedding of proteins important for SARS-CoV-2 pathogenesis in plasma of tobacco cigarette smokers compared to electronic cigarette vapers: a cross-sectional study
- Source :
- Journal of molecular medicine (Berlin, Germany), vol 101, iss 3
- Publication Year :
- 2023
- Publisher :
- Springer Science and Business Media LLC, 2023.
-
Abstract
- The impact of tobacco cigarette (TCIG) smoking and electronic cigarette (ECIG) vaping on the risk of development of severe COVID-19 is controversial. The present study investigated levels of proteins important for SARS-CoV-2 pathogenesis present in plasma because of ectodomain shedding in smokers, ECIG vapers, and non-smokers (NSs). Protein levels of soluble angiotensin-converting enzyme 2 (ACE2), angiotensin (Ang) II (the ligand of ACE2), Ang 1-7 (the main peptide generated from Ang II by ACE2 activity), furin (a protease that increases the affinity of the SARS-CoV-2 spike protein for ACE2), and products of ADAM17 shedding activity that predict morbidity in COVID-19 (IL-6/IL-6R alpha (IL-6/IL-6Rα) complex, soluble CD163 (sCD163), L-selectin) were determined in plasma from 45 NSs, 30 ECIG vapers, and 29 TCIG smokers using ELISA. Baseline characteristics of study participants did not differ among groups. TCIG smokers had increased sCD163, L-selectin compared to NSs and ECIG vapers (p 0.1 for all comparisons). Further studies are needed to determine if increased furin activity and ADAM17 shedding activity that is associated with increased plasma levels of sCD163 and L-selectin in healthy young TCIG smokers may contribute to the future development of severe COVID-19 and cardiovascular complications of post-acute COVID-19 syndrome.
- Subjects :
- Ectodomain shedding
Immunology
Electronic Nicotine Delivery Systems
Cardiovascular
Medicinal and Biomolecular Chemistry
Clinical Research
Tobacco
Drug Discovery
Humans
2.1 Biological and endogenous factors
L-Selectin
ADAM17 activity
Aetiology
Genetics (clinical)
Furin
ACE2 activity
Inflammation
Smokers
Tobacco Smoke and Health
Interleukin-6
SARS-CoV-2
Prevention
Smoking
COVID-19
Tobacco Products
Cross-Sectional Studies
Emerging Infectious Diseases
Good Health and Well Being
Oxidative stress
Molecular Medicine
Angiotensin-Converting Enzyme 2
Subjects
Details
- ISSN :
- 14321440 and 09462716
- Volume :
- 101
- Database :
- OpenAIRE
- Journal :
- Journal of Molecular Medicine
- Accession number :
- edsair.doi.dedup.....4356e02bc018805e763c5d9abea2abf3