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Dysregulated Expression of microRNA-21 and Disease-Related Genes in Human Patients and in a Mouse Model of Alport Syndrome
- Source :
- Human Gene Therapy. 30:865-881
- Publication Year :
- 2019
- Publisher :
- Mary Ann Liebert Inc, 2019.
-
Abstract
- Alport syndrome is a genetic disease caused by mutations in type IV collagen and is characterized by progressive kidney disease. The Col4α3−/− mouse model recapitulates the main features of human A...
- Subjects :
- Collagen Type IV
Male
Adolescent
Biopsy
Nephritis, Hereditary
Disease
Kidney
Autoantigens
Severity of Illness Index
Mice
Type IV collagen
microRNA
Genetics
medicine
Animals
Humans
Genetic Predisposition to Disease
Alport syndrome
Child
Molecular Biology
Gene
Genetic Association Studies
Mice, Knockout
business.industry
Gene Expression Profiling
medicine.disease
Fibrosis
Disease Models, Animal
MicroRNAs
Gene Expression Regulation
Cancer research
Molecular Medicine
Female
business
Biomarkers
Kidney disease
Subjects
Details
- ISSN :
- 15577422 and 10430342
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Human Gene Therapy
- Accession number :
- edsair.doi.dedup.....4342d753eae274c01e0d81daecd0f7b8
- Full Text :
- https://doi.org/10.1089/hum.2018.205