Back to Search
Start Over
Aging-associated alterations in epidermal function and their clinical significance
- Source :
- Aging, vol 12, iss 6, Aging (Albany NY)
- Publication Year :
- 2020
- Publisher :
- eScholarship, University of California, 2020.
-
Abstract
- Chronologically-aged skin displays multiple functional changes in both the dermis and the epidermis. It appears that epidermal dysfunction, compromised permeability homeostasis, reduced stratum corneum hydration and elevated skin surface pH predispose to the development of aging-associated cutaneous and extracutaneous disorders. Improvements in epidermal function have been shown to be an effective alternative therapy in the prevention and treatment of some aging-associated cutaneous disorders, including eczematous dermatitis, pruritus, and xerosis. Recent studies demonstrated that epidermal dysfunction leads to the development of chronic, low-grade systemic inflammation, termed 'inflammaging,' which is linked to the development of aging-associated systemic disorders. Thus, correction of epidermal dysfunction could comprise a novel strategy in the prevention and treatment of aging-associated systemic disorders as well. In this review, we summarize aging-associated alterations in epidermal function, their underlying mechanisms, and their clinical significance. Regimens to improve epidermal function in the elderly are also discussed.
- Subjects :
- Aging
Physiology
Oncology and Carcinogenesis
Review
Systemic inflammation
Cutaneous Disorders
Permeability
Dermis
emollient
Skin surface
Stratum corneum
medicine
Humans
Homeostasis
Clinical significance
epidermal permeability barrier
Aged
Skin
Inflammation
integumentary system
business.industry
pH
Evaluation of treatments and therapeutic interventions
Cell Biology
Skin Aging
medicine.anatomical_structure
6.1 Pharmaceuticals
Immunology
Eczematous dermatitis
Biochemistry and Cell Biology
medicine.symptom
Epidermis
business
hydration
Developmental Biology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Aging, vol 12, iss 6, Aging (Albany NY)
- Accession number :
- edsair.doi.dedup.....433a803775ac4f332d2e75d46b00d22c