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Colorectal Polyps in Childhood Cancer Survivors Treated with Radiation Therapy
- Source :
- Digestive diseases and sciences. 63(9)
- Publication Year :
- 2018
-
Abstract
- Cancer survivors treated with abdominal or pelvic radiation therapy (RT) for childhood cancer have an increased risk of colorectal cancer. However, clinical guidelines are inconsistent on recommendations regarding the early initiation of screening in these patients due to the lack of supporting evidence that these patients pass through a pre-invasive phase, in which adenomatous polyps can be detected and removed. To determine the prevalence of adenomatous polyps in cancer survivors treated with RT for childhood cancer; the prevalence in average-risk patients aged 17–49; and the prevalence in average-risk patients aged 50–75. We conducted a retrospective study comparing the prevalence of adenomatous polyps among three patient groups: childhood cancer survivors aged 17–49 with prior RT who underwent colonoscopy screening from 2006 to 2017; age- and gender-matched patients in the average-risk population; and average-risk patients aged 50–75. One hundred and forty-five patients were included in the study. The proportion of patients with adenomatous polyps in the cancer survivor group was significantly higher than that in the age- and gender-matched average-risk group (58.6 vs 17.2%, p = 0.00) and higher than the average-risk group aged 50–75 (58.6 vs 27.6%, p = 0.009). The prevalence of adenomas with high-risk features was higher in the survivor group compared to patients aged 50–75 (20.7 vs 3.5%, p = 0.015). Cancer survivors treated with RT for childhood cancer have a higher prevalence of adenomatous polyps compared to the average-risk population. These findings support the early initiation of colonoscopy screening 10 years after radiation therapy, even in patients who have received RT doses below 30 Gy.
- Subjects :
- Adult
Male
medicine.medical_specialty
Neoplasms, Radiation-Induced
Time Factors
Adolescent
Physiology
Colorectal cancer
medicine.medical_treatment
Population
Colonoscopy
Colonic Polyps
03 medical and health sciences
Adenomatous Polyps
Young Adult
0302 clinical medicine
Age Distribution
Cancer Survivors
Risk Factors
Internal medicine
Neoplasms
medicine
Prevalence
Humans
Age of Onset
education
Aged
Retrospective Studies
Cancer survivor
education.field_of_study
medicine.diagnostic_test
British Columbia
Radiotherapy
business.industry
Gastroenterology
Cancer
Retrospective cohort study
Middle Aged
medicine.disease
Radiation therapy
Treatment Outcome
030220 oncology & carcinogenesis
Colorectal Polyp
030211 gastroenterology & hepatology
Female
business
Colorectal Neoplasms
Subjects
Details
- ISSN :
- 15732568
- Volume :
- 63
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Digestive diseases and sciences
- Accession number :
- edsair.doi.dedup.....433867fdedfce3bc6c40f4fb5ce07930