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Herpetic keratitis in athymic (nude) mice
- Source :
- Infection and Immunity. 26:1164-1171
- Publication Year :
- 1979
- Publisher :
- American Society for Microbiology, 1979.
-
Abstract
- The inflammatory response to herpes simplex virus infection of the cornea was studied in athymic nude (nu/nu) and heterozygote (nu/+) BALB/c mice. Although athymic mice were highly susceptible to HSV infection and died 13 to 17 days after corneal inoculation, they failed to develop necrotizing keratitis of the cornea. Heterozygote mice survived the initial virual infection, but many of these mice developed necrotizing keratitis and permanent corneal scarring. Light and electron microscopy showed numerous inflammatory cells (polymorphonuclear leukocytes and lymphocytes) in the corneas of heterozygote mice, but not in the athymic mice. These studies suggest that the immune system plays a dual role in herpes simplex virus infection of the cornea: protection against dissemination of the virus and immunopathogenesis of necrotizing keratitis in the cornea.
- Subjects :
- Heterozygote
Pathology
medicine.medical_specialty
Neutrophils
viruses
Immunology
Mice, Nude
Biology
Microbiology
Virus
Keratitis
Cornea
Mice
Immune system
Immunity
medicine
Animals
Lymphocytes
Mice, Inbred BALB C
Heterozygote advantage
Keratitis, Dendritic
medicine.disease
biology.organism_classification
eye diseases
Specific Pathogen-Free Organisms
Infectious Diseases
medicine.anatomical_structure
Rickettsia
Parasitology
sense organs
Corneal scarring
Research Article
Subjects
Details
- ISSN :
- 10985522 and 00199567
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Infection and Immunity
- Accession number :
- edsair.doi.dedup.....432a022b3847d61fdffdb36c7e7dfe90