Back to Search
Start Over
Aprotinin combined with nitric oxide and prostaglandin E1 protects the canine kidney from cardiopulmonary bypass-induced injury
- Source :
- European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 38(1)
- Publication Year :
- 2009
-
Abstract
- Objective:Aprotinin is frequentlyusedto reduce bloodlossduring cardiacsurgery; however, it also causes renalinjury. Sinceaprotinin reduces nitric oxide (NO) and prostaglandin I2 (PGI2), and both cause vasodilation and inhibit activation of neutrophils and platelets, their reduction may be responsible for the injury. This study was to determine whether the combination of aprotinin with NO and prostaglandin E1 (PGE1, an analogue of PGI2) can attenuate renal injury associated with aprotinin during cardiopulmonary bypass (CPB). Methods: Thirty mongrel dogs were equally divided into five groups, with each group receiving CPB and aprotinin, NO, PGE1, a combination of the three or no treatment (control). Serum creatinine and creatinine clearance were determined. To elucidate the mechanism, neutrophil, platelet and thrombin activations were also assessed. Results: After CPB, serum creatinine increased and creatinine clearance decreased in all dogs. These changes were similar among the NO, PGE1, aprotinin and control groups, but were significantly smaller in the combination group. Similarly, myeloperoxidase activities in tissues, CD11b expression, plasma elastase, prothrombin fragment (PTF) 1 + 2 and platelet activation factor were lower, whereas neutrophil and platelet counts were higher in the combination group than in the other groups (P < 0.05). Conclusions: Aprotinin combined with NO and PGE1 produced synergistic protective effects and improved renal function, due partly to inhibition of platelet and neutrophil activation and suppression of thrombin formation. # 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
- Subjects :
- Pulmonary and Respiratory Medicine
Male
medicine.medical_specialty
Antifibrinolytic
medicine.drug_class
Vasodilator Agents
Drug Evaluation, Preclinical
Prostaglandin
Renal function
Nitric Oxide
Hemostatics
Neutrophil Activation
chemistry.chemical_compound
Aprotinin
Dogs
Internal medicine
medicine
Animals
Platelet
Platelet activation
Alprostadil
Prostaglandin E1
Creatinine
Cardiopulmonary Bypass
business.industry
General Medicine
Acute Kidney Injury
Platelet Activation
Endocrinology
chemistry
Surgery
Drug Therapy, Combination
Cardiology and Cardiovascular Medicine
business
Platelet Aggregation Inhibitors
circulatory and respiratory physiology
medicine.drug
Subjects
Details
- ISSN :
- 1873734X
- Volume :
- 38
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
- Accession number :
- edsair.doi.dedup.....4329ac16b033e64a16b10bd806a8764d