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Bio‐adhesive Nanoporous Module: Toward Autonomous Gating
- Source :
- Angewandte Chemie International Edition. 60:8932-8937
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Here we report a bio-adhesive porous organic module (Glue COF) composed of hexagonally packed 1D nanopores based on a covalent organic framework. The nanopores are densely decorated with guanidinium ion (Gu+ ) pendants capable of forming salt bridges with oxyanionic species. Glue COF strongly adheres to biopolymers through multivalent salt-bridging interactions with their ubiquitous oxyanionic species. By taking advantage of its strong bio-adhesive nature, we succeeded in creating a gate that possibly opens the nanopores through a selective interaction with a reporter chemical and releases guest molecules. We chose calmodulin (CaM) as a gating component that can stably entrap a loaded guest, sulforhodamine B (SRB), within the nanopores (CaM COF⊃SRB). CaM is known to change its conformation on binding with Ca2+ ions. We confirmed that mixing CaM COF⊃SRB with Ca2+ resulted in the release of SRB from the nanopores, whereas the use of weakly binding Mg2+ ions resulted in a much slower release of SRB.
- Subjects :
- Calmodulin
biology
010405 organic chemistry
Chemistry
Nanoporous
Sulforhodamine B
General Chemistry
Gating
010402 general chemistry
01 natural sciences
Catalysis
0104 chemical sciences
chemistry.chemical_compound
Nanopore
Chemical engineering
biology.protein
Molecule
Host–guest chemistry
Covalent organic framework
Subjects
Details
- ISSN :
- 15213773 and 14337851
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie International Edition
- Accession number :
- edsair.doi.dedup.....4311b1949d52d8b51344ef772d102dd8