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Ryanodine Receptor Adaptation

Authors :
Sandor Gyorke
Carlos A. Villalba-Galea
Ivan Zahradník
Alexandra Zahradníková
Ariel L. Escobar
Michael Fill
Source :
The Journal of General Physiology
Publication Year :
2000
Publisher :
Rockefeller University Press, 2000.

Abstract

In the heart, depolarization during the action potential activates voltage-dependent Ca2+ channels that mediate a small, localized Ca2+ influx (ICa). This small Ca2+ signal activates specialized Ca2+ release channels, the ryanodine receptors (RyRs), in the sarcoplasmic reticulum (SR). This process

Details

ISSN :
15407748 and 00221295
Volume :
116
Database :
OpenAIRE
Journal :
Journal of General Physiology
Accession number :
edsair.doi.dedup.....430b7851af988a6ca48ac6f1aff13f3a