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The status of Her2 amplification and Kras mutations in mucinous ovarian carcinoma
- Source :
- Human Genomics
- Publication Year :
- 2016
- Publisher :
- BioMed Central, 2016.
-
Abstract
- Epithelial ovarian cancer is the commonest cause of gynaecological cancer-associated death. The disease typically presents in postmenopausal women, with a few months of abdominal pain and distension. Most women have advanced disease (International Federation of Gynecology and Obstetrics [FIGO] stage III), for which the standard of care remains surgery and platinum-based cytotoxic chemotherapy. Although this treatment can be curative for most patients with early stage disease, most women with advanced disease will develop many episodes of recurrent disease with progressively shorter disease-free intervals. These episodes culminate in chemoresistance and ultimately bowel obstruction, the most frequent cause of death. For women whose disease continues to respond to platinum-based drugs, the disease can often be controlled for 5 years or more. Targeted treatments such as antiangiogenic drugs or poly (ADP-ribose) polymerase inhibitors offer potential for improved survival. The efficacy of screening, designed to detect the disease at an earlier and curable stage remains unproven, with key results expected in 2015.
- Subjects :
- 0301 basic medicine
endocrine system diseases
Genes, BRCA2
Genes, BRCA1
Angiogenesis Inhibitors
Carcinoma, Ovarian Epithelial
medicine.disease_cause
Kras mutation
0302 clinical medicine
Mucinous ovarian carcinoma
Ovarian carcinoma
Drug Discovery
HER2 Amplification
Neoplasm Metastasis
skin and connective tissue diseases
Letter to the Editor
Early Detection of Cancer
Ovarian Neoplasms
Hybridization probe
Her2 amplification
Middle Aged
Prognosis
Adenocarcinoma, Mucinous
030220 oncology & carcinogenesis
Molecular Medicine
Female
KRAS
Mucinous cystadenocarcinoma
Hormone Replacement Therapy
Antineoplastic Agents
Poly(ADP-ribose) Polymerase Inhibitors
Proto-Oncogene Proteins p21(ras)
03 medical and health sciences
Genetics
medicine
Humans
Molecular Biology
neoplasms
Germ-Line Mutation
business.industry
medicine.disease
digestive system diseases
030104 developmental biology
Mutation
Cancer research
Neoplasm Recurrence, Local
Ovarian cancer
business
Forecasting
Subjects
Details
- Language :
- English
- ISSN :
- 14797364 and 14739542
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Human Genomics
- Accession number :
- edsair.doi.dedup.....42fd7c5778318b5fa5f025bde6ecc8d6