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Morpholine containing CB2 selective agonists

Authors :
Angela Berry
David S. Thomson
Doris Riether
Sabine Löbbe
Todd Bosanac
Andreas Ebneth
Diane Thome
Ernest L. Raymond
Daw-Tsun Shih
Renee Zindell
Mark J. Gemkow
Source :
Bioorganic & Medicinal Chemistry Letters. 19:1604-1609
Publication Year :
2009
Publisher :
Elsevier BV, 2009.

Abstract

Identification and optimization of two classes of CB2 selective agonists are described. A representative from each class is profiled in a murine model of inflammation and each shows similar efficacy to prednisolone upon oral dosing.

Details

ISSN :
0960894X
Volume :
19
Database :
OpenAIRE
Journal :
Bioorganic & Medicinal Chemistry Letters
Accession number :
edsair.doi.dedup.....42f7d483f36825c54620336853737fe4
Full Text :
https://doi.org/10.1016/j.bmcl.2009.02.033