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Effect and safety of Chinese herbal medicine granules in patients with severe coronavirus disease 2019 in Wuhan, China: a retrospective, single-center study with propensity score matching
- Source :
- Phytomedicine
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background Chinese herbal medicine (CHM) has been used for severe illness caused by coronavirus disease 2019 (COVID-19), but its treatment effects and safety are unclear. Purpose This study reviews the effect and safety of CHM granules in the treatment of patients with severe COVID-19. Methods We conducteda single-center, retrospective study on patients with severe COVID-19 in a designated hospital in Wuhan from January 15, 2020 to March 30, 2020. The propensity score matching (PSM) was used to assess the effect and safety of the treatment using CHM granules. The ratio of patients who received treatment with CHM granules combined with usual care and those who received usual care alone was 1:1. The primary outcome was the time to clinical improvement within 28 days, defined as the time taken for the patients’ health to show improvement by decline of two categories (from the baseline) on a modified six-category ordinal scale, or to be dischargedfrom the hospital before Day 28. Results Using PSM, 43 patients (45% male) aged 65.6 (57–70) yearsfrom each group were exactly matched. No significant difference was observed in clinical improvement of patients treated with CHM granules compared with those who received usual (p = 0.851). However, the use of CHM granules reduced the 28-day mortality (p = 0.049) and shortened the duration of fever (4 days vs. 7 days, p = 0.002). The differences in the duration of cough and dyspnea and the difference in lung lesion ratio on computerized tomography scans were not significant.Commonly,patients in the CHM group had an increased D -dimer level (p = 0.036). Conclusion Forpatients with severe COVID-19, CHM granules, combined with usual care, showed no improvement beyond usual care alone. However, the use of CHM granules reduced the 28-day mortality rate and the time to fever alleviation. Nevertheless, CHM granules may be associated with high risk of fibrinolysis.
- Subjects :
- Male
CHM: Chinese herbal medicine
medicine.medical_treatment
RRR: relative risk reduction
Pharmaceutical Science
Single Center
0302 clinical medicine
Drug Discovery
0303 health sciences
IQR: interquartile range
Mortality rate
Middle Aged
CT: computerized tomography
ECMO: extracorporeal membrane oxygenation
030220 oncology & carcinogenesis
Molecular Medicine
Female
Chinese herbal medicine
NNT: number needed to treat
China
medicine.medical_specialty
Fever
Coronavirus disease 2019 (COVID-19)
RR: respiratory rate
Article
03 medical and health sciences
Internal medicine
Fibrinolysis
ARR: absolute risk reduction
medicine
Humans
In patient
Propensity Score
Aged
Retrospective Studies
030304 developmental biology
PSM: propensity score matching
Pharmacology
NTproBNP: N-terminal prohormone of brain natriuretic peptide
COVID-19: coronavirus disease 2019
TCM: traditional Chinese medicine
business.industry
SARS: severe acute respiratory syndrome
COVID-19
Retrospective cohort study
COVID-19 Drug Treatment
WHO: World Health Organization
Complementary and alternative medicine
Propensity score matching
Usual care
business
Drugs, Chinese Herbal
propensity score matching Abbreviations AEs: Adverse events
Subjects
Details
- ISSN :
- 09447113
- Volume :
- 85
- Database :
- OpenAIRE
- Journal :
- Phytomedicine
- Accession number :
- edsair.doi.dedup.....42f3098521fa498abd6bc735350e342d