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Impact and Control of Sugar Size in Glycoconjugate Vaccines
- Source :
- Molecules (Basel, Switzerland). 27(19)
- Publication Year :
- 2022
-
Abstract
- Glycoconjugate vaccines have contributed enormously to reducing and controlling encapsulated bacterial infections for over thirty years. Glycoconjugate vaccines are based on a carbohydrate antigen that is covalently linked to a carrier protein; this is necessary to cause T cell responses for optimal immunogenicity, and to protect young children. Many interdependent parameters affect the immunogenicity of glycoconjugate vaccines, including the size of the saccharide antigen. Here, we examine and discuss the impact of glycan chain length on the efficacy of glycoconjugate vaccines and report the methods employed to size polysaccharide antigens, while highlighting the underlying reaction mechanisms. A better understanding of the impact of key parameters on the immunogenicity of glycoconjugates is critical to developing a new generation of highly effective vaccines.
- Subjects :
- Carbohydrates
Pharmaceutical Science
immunogenicity
Analytical Chemistry
fragmentation of polysaccharides
glycoconjugates
sugar length
vaccine
Antigens
Carrier Proteins
Child
Child, Preschool
Humans
Polysaccharides
Vaccines, Conjugate
Glycoconjugates
Sugars
Drug Discovery
Physical and Theoretical Chemistry
Preschool
Conjugate
Vaccines
Organic Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 27
- Issue :
- 19
- Database :
- OpenAIRE
- Journal :
- Molecules (Basel, Switzerland)
- Accession number :
- edsair.doi.dedup.....42e2749cda2158cec23e4a5b52f926c1