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A novel segmentation framework dedicated to the follow‐up of fat infiltration in individual muscles of patients with neuromuscular disorders
- Source :
- Magnetic Resonance in Medicine, Magnetic Resonance in Medicine, Wiley, 2019, 83 (5), pp.1825-1836. ⟨10.1002/mrm.28030⟩, Magnetic Resonance in Medicine, 83, 1825-1836, Magnetic Resonance in Medicine, 2019, 83 (5), pp.1825-1836. ⟨10.1002/mrm.28030⟩, Magnetic Resonance in Medicine, 83, 5, pp. 1825-1836
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- International audience; Purpose: To propose a novel segmentation framework that is dedicated to the follow-up of fat infiltration in individual muscles of patients with neuromuscular disorders.Methods: We designed a semi-automatic segmentation pipeline of individual leg muscles in MR images based on automatic propagation through nonlinear registrations of initial delineation in a minimal number of MR slices. This approach has been validated for the segmentation of individual muscles from MRI data sets, acquired over a 10-month period, from thighs and legs in 10 patients with muscular dystrophy. The robustness of the framework was evaluated using conventional metrics related to muscle volume and clinical metrics related to fat infiltration.Results: High accuracy of the semi-automatic segmentation (mean Dice similarity coefficient higher than 0.89) was reported. The provided method has excellent reliability regarding the reproducibility of the fat fraction estimation, with an average intraclass correlation coefficient score of 0.99. Furthermore, the present segmentation framework was determined to be more reliable than the intra-expert performance, which had an average intraclass correlation coefficient of 0.93.Conclusion: The proposed framework of segmentation can successfully provide an effective and reliable tool for accurate follow-up of any MRI biomarkers in neuromuscular disorders. This method could assist the quantitative assessment of muscular changes occurring in such diseases.
- Subjects :
- Intraclass correlation
Fat infiltration
Image registration
Muscle volume
030218 nuclear medicine & medical imaging
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
0302 clinical medicine
Urological cancers Radboud Institute for Molecular Life Sciences [Radboudumc 15]
Quantitative assessment
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging
Humans
Medicine
Radiology, Nuclear Medicine and imaging
Segmentation
ComputingMilieux_MISCELLANEOUS
Leg
Reproducibility
business.industry
Reproducibility of Results
Image segmentation
Magnetic Resonance Imaging
Thigh
business
Algorithms
030217 neurology & neurosurgery
Follow-Up Studies
Biomedical engineering
Subjects
Details
- Language :
- English
- ISSN :
- 07403194 and 15222594
- Database :
- OpenAIRE
- Journal :
- Magnetic Resonance in Medicine, Magnetic Resonance in Medicine, Wiley, 2019, 83 (5), pp.1825-1836. ⟨10.1002/mrm.28030⟩, Magnetic Resonance in Medicine, 83, 1825-1836, Magnetic Resonance in Medicine, 2019, 83 (5), pp.1825-1836. ⟨10.1002/mrm.28030⟩, Magnetic Resonance in Medicine, 83, 5, pp. 1825-1836
- Accession number :
- edsair.doi.dedup.....42e0bad4a0932b1645e9a5e346937dd0