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Rationale and Design of the Genetic Contribution to Drug Induced Renal Injury (DIRECT) Study
- Source :
- Kidney International Reports, Kidney international reports, vol 1, iss 4, Kidney International Reports, Vol 1, Iss 4, Pp 288-298 (2016)
- Publication Year :
- 2016
- Publisher :
- Elsevier, 2016.
-
Abstract
- Introduction Nephrotoxicity from drugs accounts for 18% to 27% of cases of acute kidney injury. Determining a genetic predisposition may potentially be important in minimizing risk. The aims of this study are as follows: to determine whether a genetic predisposition exists for the development of drug-induced kidney disease (DIKD), using genome-wide association and whole-genome sequencing studies; to describe the frequency, course, risk factors, resolution and outcomes of DIKD cases; to investigate the role of ethnic/racial variability in the genetics of DIKD; and to explore the use of different tools establishing causality of DIKD. Methods A total of 800 patients will be enrolled worldwide and blood samples for DNA collected. Data on the patient risk factors, vital signs, laboratory parameters, drug exposure, and DIKD course will be recorded. A panel of nephrologists will adjudicate all cases. Genome-wide association studies will be conducted using population controls matched on biogeographic ancestry to determine whether there is a genetic predisposition to DIKD. The primary endpoint is the identification of specific drug-related polymorphisms associated with DIKD. Secondary endpoints include the following: frequency of DIKD by causal drug and drug combinations; DIKD genetic variability; exploration of causality assessment tools; risk factor identification; description of the course of DIKD, including mortality and dialysis dependency at hospital discharge and 28 and 90 days post-event. Results Data are currently being analyzed. Results are pending. Discussion The Genetic Contribution to Drug Induced Renal Injury (DIRECT) study will be the first observational cohort study to investigate the genetic determinants of DIKD. If the trial is positive, its findings will potentially translate into safer patient outcomes, by genotypic individualization of therapy and minimization of harm.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
NSAIDs
Population
030232 urology & nephrology
Pharmacology
lcsh:RC870-923
antimicrobials
03 medical and health sciences
0302 clinical medicine
AKI
Clinical Research
medicine
Genetic predisposition
Clinical endpoint
Genetic variability
Risk factor
Intensive care medicine
education
pharmacogenomics
education.field_of_study
business.industry
nephrotoxicity
lcsh:Diseases of the genitourinary system. Urology
medicine.disease
calcineurin inhibitors
030104 developmental biology
Nephrology
Pharmacogenomics
business
Kidney disease
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 24680249
- Volume :
- 1
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Kidney International Reports
- Accession number :
- edsair.doi.dedup.....42d34825a88be4442612e4df57e2bf86