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Anti-NF155 chronic inflammatory demyelinating polyradiculoneuropathy strongly associates to HLA-DRB15
- Source :
- Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-6 (2017), Journal of Neuroinflammation, r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol, instname, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
- Publication Year :
- 2017
-
Abstract
- Background The aim of the research is to study the human leukocyte antigen (HLA) class II allele frequencies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) associated with anti-neurofascin 155 (NF155) antibodies. Methods Thirteen anti-NF155+ and 35 anti-NF155 negative (anti-NF155neg) CIDP patients were included in a case-control study. The frequencies of the DRB1 HLA allele were analyzed in all patients while DQ frequencies were only studied in patients sharing the DRB1*15 allele. In silico HLA-peptide binding and NF155 antigenicity, predictions were performed to analyze overlap between presented peptides and antigenic regions. Results DRB1*15 alleles (DRB1*15:01 and DRB1*15:02) were present in 10 out of 13 anti-NF155+ CIDP patients and in only 5 out of 35 anti-NF155neg CIDP patients (77 vs 14%; OR = 20, CI = 4.035 to 99.13). DRB1*15 alleles appeared also in significantly higher proportions in anti-NF155+ CIDP than in normal population (77 vs 17%; OR = 16.9, CI = 4.434 to 57.30). Seven anti-NF155+ CIDP patients (53%) and 5 anti-NF155neg CIDP patients had the DRB1*15:01 allele (OR = 7, p = 0.009), while 3 anti-NF155+ CIDP patients and none of the anti-NF155neg CIDP patients had the DRB1*15:02 allele (OR = 23.6, p = 0.016). In silico analysis of the NF155 peptides binding to DRB1*15 alleles showed significant overlap in the peptides presented by the 15:01 and 15:02 alleles, suggesting functional homology. Conclusions DRB1*15 alleles are the first strong risk factor associated to a CIDP subset, providing additional evidence that anti-NF155+ CIDP patients constitute a differentiated disease within the CIDP syndrome. Electronic supplementary material The online version of this article (10.1186/s12974-017-0996-1) contains supplementary material, which is available to authorized users.
- Subjects :
- 0301 basic medicine
Adult
Male
Genotype
Immunology
Human leukocyte antigen
CIDP
Autoantigens
lcsh:RC346-429
Antibodies
HLA DRB1*15
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Antigen
Gene Frequency
Medicine
Humans
Genetic Predisposition to Disease
Nerve Growth Factors
Risk factor
Allele
HLA-DRB1
Allele frequency
lcsh:Neurology. Diseases of the nervous system
Aged
Autoantibodies
biology
business.industry
General Neuroscience
Research
Polyradiculoneuropathy
NF155
Middle Aged
medicine.disease
030104 developmental biology
Neurology
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Case-Control Studies
biology.protein
Female
Antibody
business
Cell Adhesion Molecules
030217 neurology & neurosurgery
HLA-DRB1 Chains
Subjects
Details
- Language :
- English
- ISSN :
- 17422094
- Database :
- OpenAIRE
- Journal :
- Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-6 (2017), Journal of Neuroinflammation, r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol, instname, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
- Accession number :
- edsair.doi.dedup.....42c737363521fdf7dc61ce951ed10663