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'Scratch it out': carbon copy based paper devices for microbial assays and liver disease diagnosis
- Source :
- Analytical methods : advancing methods and applications. 13(28)
- Publication Year :
- 2021
-
Abstract
- We present a facile paper-based microfluidic device fabrication technique leveraging off-the-shelf carbon paper for the deposition of hydrophobic barriers using a novel "stencil scratching" method. This exceedingly frugal approach (0.05$) requires practically no technical training to employ. Hydrophobic barriers fabricated using this approach offer a width of 3 mm and a hydrophilic channel width of 849 μm, with an ability to confine major aqueous solvents without leakage. The utility of the device is demonstrated by porting a cell viability assay showing a limit-of-detection (LOD) of 0.6 × 108 CFU mL-1 and bilirubin assay with human serum showing a detection range of 1.76-6.9 mg dL-1 and a limit-of-detection (LOD) of 1.76 mg dL-1. The intuitiveness and economic viability of the fabrication method afford it great potential in the field of point-of-care diagnostics geared towards providing testing infrastructure in resource-scarce regions globally.
- Subjects :
- Paper
Carbon copy
Fabrication
Materials science
General Chemical Engineering
Liver Diseases
Microfluidics
General Engineering
Nanotechnology
Stencil
Analytical Chemistry
Scratch
Point-of-Care Testing
Technical training
Humans
Viability assay
computer
Hydrophobic and Hydrophilic Interactions
Leakage (electronics)
computer.programming_language
Subjects
Details
- ISSN :
- 17599679
- Volume :
- 13
- Issue :
- 28
- Database :
- OpenAIRE
- Journal :
- Analytical methods : advancing methods and applications
- Accession number :
- edsair.doi.dedup.....42c3728fb19275a1c6692d31b1f39c15