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Intake of Docosahexaenoic Acid-Enriched Milk Beverage Prevents Age-Related Cognitive Decline and Decreases Serum Bone Resorption Marker Levels

Authors :
Yoko Tanabe
Miho Ohno
Harumi Wakatsuki
Setsushi Kato
Kato Masaharu
Takashi Ichinose
Miwako Morikawa
Michio Hashimoto
Osamu Shido
Shuuzo Ohata
Shahdat Hossain
Kentaro Matsuzaki
Nobuhiko Tachibana
Source :
Journal of Oleo Science. 70:1829-1838
Publication Year :
2021
Publisher :
Japan Oil Chemists' Society, 2021.

Abstract

The pathogenic mechanism of dementia is still unknown, and the fundamental treatment remains to be established. Thus, there is growing interest in preventing dementia through diet. One of the functional ingredients attracting attention is docosahexaenoic acid. We conducted a 12-month, randomized, double-blind, placebo-controlled clinical trial in healthy elderly Japanese individuals with a Mini-Mental State Examination score of 28 or higher at baseline using a docosahexaenoic acid-enriched milk beverage containing 297 mg docosahexaenoic acid and 137 mg eicosapentaenoic acid. Consumption of a docosahexaenoic acid-enriched milk beverage increased the fatty acid levels of docosahexaenoic acid and eicosapentaenoic acid in erythrocyte membranes, which was the primary outcome of this study. Moreover, intake of this beverage prevented age-related cognitive decline and decreased serum bone resorption marker levels. Our data demonstrate that, even at a low dose, long-term daily intake of docosahexaenoic acid prevents dementia and may show beneficial effect on bone health.

Details

ISSN :
13473352 and 13458957
Volume :
70
Database :
OpenAIRE
Journal :
Journal of Oleo Science
Accession number :
edsair.doi.dedup.....42c00fd5a4d84ae3799e0ae8ca0d1d71
Full Text :
https://doi.org/10.5650/jos.ess21195