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Intake of Docosahexaenoic Acid-Enriched Milk Beverage Prevents Age-Related Cognitive Decline and Decreases Serum Bone Resorption Marker Levels
- Source :
- Journal of Oleo Science. 70:1829-1838
- Publication Year :
- 2021
- Publisher :
- Japan Oil Chemists' Society, 2021.
-
Abstract
- The pathogenic mechanism of dementia is still unknown, and the fundamental treatment remains to be established. Thus, there is growing interest in preventing dementia through diet. One of the functional ingredients attracting attention is docosahexaenoic acid. We conducted a 12-month, randomized, double-blind, placebo-controlled clinical trial in healthy elderly Japanese individuals with a Mini-Mental State Examination score of 28 or higher at baseline using a docosahexaenoic acid-enriched milk beverage containing 297 mg docosahexaenoic acid and 137 mg eicosapentaenoic acid. Consumption of a docosahexaenoic acid-enriched milk beverage increased the fatty acid levels of docosahexaenoic acid and eicosapentaenoic acid in erythrocyte membranes, which was the primary outcome of this study. Moreover, intake of this beverage prevented age-related cognitive decline and decreased serum bone resorption marker levels. Our data demonstrate that, even at a low dose, long-term daily intake of docosahexaenoic acid prevents dementia and may show beneficial effect on bone health.
- Subjects :
- Male
medicine.medical_specialty
Age-related cognitive decline
Docosahexaenoic Acids
General Chemical Engineering
Bone resorption
Eating
Asian People
Double-Blind Method
Internal medicine
medicine
Animals
Humans
Dementia
Cognitive Dysfunction
Bone Resorption
Cognitive decline
Aged
chemistry.chemical_classification
Tartrate-Resistant Acid Phosphatase
business.industry
Erythrocyte Membrane
Fatty acid
General Medicine
General Chemistry
Healthy elderly
Middle Aged
Alkaline Phosphatase
medicine.disease
Eicosapentaenoic acid
Milk
Endocrinology
Eicosapentaenoic Acid
chemistry
Cognitive Aging
Docosahexaenoic acid
Dietary Supplements
Female
business
Biomarkers
Subjects
Details
- ISSN :
- 13473352 and 13458957
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Journal of Oleo Science
- Accession number :
- edsair.doi.dedup.....42c00fd5a4d84ae3799e0ae8ca0d1d71
- Full Text :
- https://doi.org/10.5650/jos.ess21195