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Effects of primary resuscitation from shock on distribution of myocardial blood flow
- Source :
- Journal of Applied Physiology. 88:373-385
- Publication Year :
- 2000
- Publisher :
- American Physiological Society, 2000.
-
Abstract
- Hemorrhagic shock alters heterogeneity of regional myocardial perfusion (RMP) in the presence of critical coronary stenosis in pigs. Conventional resuscitation has failed to reverse these effects. We hypothesized that improvement of the resuscitation regime would lead to restoration of RMP heterogeneity. Diaspirin-cross-linked hemoglobin (10 g/dl; DCLHb) and human serum albumin (8.0 g/dl; HSA) were used. After baseline, a branch of the left coronary artery was stenosed; thereafter, hemorrhagic shock was induced. Resuscitation was performed with either DCLHb or HSA. At baseline, the fractcal dimension ( D) of subendocardial myocardium was 1.31 ± 0.083 (HSA) and 1.35 ± 0.106 (DCLHb) (mean ± SD). Coronary stenosis increased subendocardial D slightly but consistently only in the DCLHb group (1.39 ± 0.104; P < 0.05). Shock reduced subendocardial D: 1.21 ± 0.093 (HSA; P = 0.10), 1.25 ± 0.092 (DCLHb; P < 0.05). Administration of DCLHb increased subendocardial D in 7 of 10 animals (1.31 ± 0.097; P = 0.066). HSA was ineffective in this respect. DCLHb infusion restored arterial pressure and increased cardiac index (CI) to 80% of baseline values. Administration of HSA left animals hypotensive (69 mmHg) and increased CI to 122% of the average baseline value. Shock-induced disturbances of the distribution of RMP were improved by administration of DCLHb but not by HSA.
- Subjects :
- Resuscitation
Swine
Physiology
Hemodynamics
Shock, Hemorrhagic
Hemoglobins
Coronary circulation
Coronary Circulation
Physiology (medical)
medicine
Animals
Humans
Distribution (pharmacology)
Serum Albumin
Aspirin
business.industry
Blood flow
Middle Aged
Coronary Vessels
medicine.anatomical_structure
Shock (circulatory)
Anesthesia
Hypotension
medicine.symptom
business
Perfusion
medicine.drug
Subjects
Details
- ISSN :
- 15221601 and 87507587
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- Journal of Applied Physiology
- Accession number :
- edsair.doi.dedup.....42b82a571607a35306f714dadd7f63c9