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Cysteine Aminotransferase (CAT): A Pivotal Sponsor in Metabolic Remodeling and an Ally of 3-Mercaptopyruvate Sulfurtransferase (MST) in Cancer
- Source :
- Molecules, Vol 25, Iss 3984, p 3984 (2020), Molecules
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Metabolic remodeling is a critical skill of malignant cells, allowing their survival and spread. The metabolic dynamics and adaptation capacity of cancer cells allow them to escape from damaging stimuli, including breakage or cross-links in DNA strands and increased reactive oxygen species (ROS) levels, promoting resistance to currently available therapies, such as alkylating or oxidative agents. Therefore, it is essential to understand how metabolic pathways and the corresponding enzymatic systems can impact on tumor behavior. Cysteine aminotransferase (CAT) per se, as well as a component of the CAT: 3-mercaptopyruvate sulfurtransferase (MST) axis, is pivotal for this metabolic rewiring, constituting a central mechanism in amino acid metabolism and fulfilling the metabolic needs of cancer cells, thereby supplying other different pathways. In this review, we explore the current state-of-art on CAT function and its role on cancer cell metabolic rewiring as MST partner, and its relevance in cancer cells’ fitness.
- Subjects :
- Pharmaceutical Science
Sulfurtransferase
Oxidative phosphorylation
Review
Biology
Analytical Chemistry
lcsh:QD241-441
03 medical and health sciences
0302 clinical medicine
lcsh:Organic chemistry
metabolic remodeling
Neoplasms
Drug Discovery
medicine
cancer
Animals
Humans
3-mercaptopyruvate sulfurtransferase (MST)
Molecular Targeted Therapy
Physical and Theoretical Chemistry
Transaminases
030304 developmental biology
chemistry.chemical_classification
0303 health sciences
Reactive oxygen species
Organic Chemistry
cysteine aminotransferase (CAT)
Cancer
3-mercaptopyruvate sulfurtransferase (MST), cancer
medicine.disease
Cell biology
Metabolic pathway
Enzyme
chemistry
Chemistry (miscellaneous)
030220 oncology & carcinogenesis
Sulfurtransferases
Cancer cell
Molecular Medicine
Function (biology)
Metabolic Networks and Pathways
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 25
- Issue :
- 3984
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....42995a55dd09a50adfbf30442872db21