Back to Search
Start Over
Broad relays hormone signals to regulate stem cell differentiation in Drosophila midgut during metamorphosis
- Source :
- Development. 139:3917-3925
- Publication Year :
- 2012
- Publisher :
- The Company of Biologists, 2012.
-
Abstract
- Like the mammalian intestine, the Drosophila adult midgut is constantly replenished by multipotent intestinal stem cells (ISCs). Although it is well known that adult ISCs arise from adult midgut progenitors (AMPs), relatively little is known about the mechanisms that regulate AMP specification. Here, we demonstrate that Broad (Br)-mediated hormone signaling regulates AMP specification. Br is highly expressed in AMPs temporally during the larva-pupa transition stage, and br loss of function blocks AMP differentiation. Furthermore, Br is required for AMPs to develop into functional ISCs. Conversely, br overexpression drives AMPs toward premature differentiation. In addition, we found that Br and Notch (N) signaling function in parallel pathways to regulate AMP differentiation. Our results reveal a molecular mechanism whereby Br-mediated hormone signaling directly regulates stem cells to generate adult cells during metamorphosis.
- Subjects :
- media_common.quotation_subject
Cellular differentiation
Biology
Animals
Drosophila Proteins
Progenitor cell
Metamorphosis
Receptor
Molecular Biology
Loss function
media_common
Receptors, Notch
Stem Cells
fungi
Metamorphosis, Biological
Development and Stem Cells
Cell Differentiation
Midgut
Cell biology
Gastrointestinal Tract
Immunology
Drosophila
Stem cell
Function (biology)
Signal Transduction
Transcription Factors
Developmental Biology
Subjects
Details
- ISSN :
- 14779129 and 09501991
- Volume :
- 139
- Database :
- OpenAIRE
- Journal :
- Development
- Accession number :
- edsair.doi.dedup.....4295a80896267a62df95e17dd0f2ad37