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The Role of Renal Progenitors in Renal Regeneration
- Source :
- Nephron. 132:101-109
- Publication Year :
- 2016
- Publisher :
- S. Karger AG, 2016.
-
Abstract
- The adult kidney has a remarkable ability to survive injury and restore function despite a limited turnover of cells under physiologic conditions. This accounts both for the tubular and to a lesser extent for the glomerular compartment. It is an ongoing debate whether renal repair is carried out by self-duplication/de-differentiation of mature resident renal cells, or by specialized renal progenitors residing in specific niches or by circulating bone marrow-derived stem cells. In this review, the existence of renal progenitor cells and their contribution for regeneration of the tubular and the glomerular compartment are discussed, highlighting landmark publications of recent years.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Kidney Glomerulus
030232 urology & nephrology
Kidney
urologic and male genital diseases
Podocyte
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Humans
Regeneration
Progenitor cell
Renal stem cell
urogenital system
business.industry
Stem Cells
Regeneration (biology)
Kidney Tubules
030104 developmental biology
medicine.anatomical_structure
Renal physiology
Stem cell
business
Subjects
Details
- ISSN :
- 22353186 and 16608151
- Volume :
- 132
- Database :
- OpenAIRE
- Journal :
- Nephron
- Accession number :
- edsair.doi.dedup.....428e9626ae540e54307066c1bdc79f93