Back to Search
Start Over
Genetic background of high blood pressure is associated with reduced mortality in premature neonates
- Source :
- Archives of Disease in Childhood. Fetal and Neonatal Edition
- Publication Year :
- 2019
- Publisher :
- BMJ, 2019.
-
Abstract
- ObjectiveThe aim of our study was to determine if a genetic background of high blood pressure is a survival factor in preterm infants.DesignProspective cohort study.SettingPatients were enrolled in 53 neonatal intensive care units.PatientsPreterm infants with a birth weight below 1500 g.ExposuresGenetic score blood pressure estimates were calculated based on adult data. We compared infants with high genetic blood pressure estimates (>75th percentile of the genetic score) to infants with low genetic blood pressure estimates (Main outcome measuresLowest blood pressure on the first day of life and mortality.Results5580 preterm infants with a mean gestational age of 28.1±2.2 weeks and a mean birth weight of 1022±299 g were genotyped and analysed. Infants with low genetic blood pressure estimates had significantly lower blood pressure if compared with infants with high genetic blood pressure estimates (27.3±6.2vs 27.9±6.4, p=0.009, t-test). Other risk factors for low blood pressure included low gestational age (−1.26 mm Hg/week) and mechanical ventilation (−2.24 mm Hg, pConclusionsOur study provides first evidence that a genetic background of high blood pressure may be beneficial with regard to survival of preterm infants.
- Subjects :
- Male
hypotension
medicine.medical_specialty
Percentile
Pediatrics
Genotype
medicine.medical_treatment
Birth weight
Blood Pressure
Gestational Age
neonatology
03 medical and health sciences
0302 clinical medicine
Risk Factors
Intensive Care Units, Neonatal
030225 pediatrics
Intensive care
Humans
Infant, Very Low Birth Weight
Medicine
genetics
Genetic Predisposition to Disease
Prospective Studies
030212 general & internal medicine
Neonatology
Prospective cohort study
Perinatal Mortality
Original Research
Mechanical ventilation
business.industry
Infant, Newborn
Infant
Obstetrics and Gynecology
Gestational age
General Medicine
mortality
3. Good health
Blood pressure
Hypertension
Pediatrics, Perinatology and Child Health
Female
business
Infant, Premature
Subjects
Details
- ISSN :
- 14682052 and 13592998
- Volume :
- 105
- Database :
- OpenAIRE
- Journal :
- Archives of Disease in Childhood - Fetal and Neonatal Edition
- Accession number :
- edsair.doi.dedup.....428c9925c0473dd12809f25371bdcbfc