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Area postrema and adjacent nucleus of the solitary tract in water and sodium balance
- Source :
- The American journal of physiology. 247(1 Pt 2)
- Publication Year :
- 1984
-
Abstract
- Lesions of the area postrema (AP) and adjacent caudal medial nucleus of the solitary tract (cmNTS) cause significant changes in water and sodium balance. Lesioned rats display a permanent polydipsia, which in part is due to a primary polyuria. Water-to-food ratios are elevated chronically. Lesioned rats are unable to concentrate their urine as well as controls. In addition, lesioned rats overdrink in response to 24-h water deprivation. This lesion also causes a natriuresis and an overconsumption of 3% NaCl solution. These findings establish the AP-cmNTS as an important part of the neurocircuitry underlying water and sodium balance.
- Subjects :
- Male
medicine.medical_specialty
Physiology
Sodium
Drinking
chemistry.chemical_element
Natriuresis
Cerebral Ventricles
Lesion
Kidney Concentrating Ability
Eating
Polyuria
Physiology (medical)
Internal medicine
medicine
Animals
Medulla Oblongata
Water Deprivation
Area postrema
Body Weight
Osmolar Concentration
Solitary tract
Rats, Inbred Strains
Water-Electrolyte Balance
Rats
Endocrinology
chemistry
Medulla oblongata
medicine.symptom
Polydipsia
Subjects
Details
- ISSN :
- 00029513
- Volume :
- 247
- Issue :
- 1 Pt 2
- Database :
- OpenAIRE
- Journal :
- The American journal of physiology
- Accession number :
- edsair.doi.dedup.....427f3953681c152560241daef557104d