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Edge-enhancing gradient echo with multi-image co-registration and averaging (EDGE-MICRA) for targeting thalamic centromedian and parafascicular nuclei
- Source :
- Neuroradiol J
- Publication Year :
- 2021
- Publisher :
- SAGE Publications, 2021.
-
Abstract
- Background and purpose Deep brain stimulation of the thalamus is an effective treatment for multiple neurological disorders. The centromedian and parafascicular nuclei are recently emerging targets for multiple conditions, such as epilepsy and Tourette syndrome; however, their limited visibility on conventional magnetic resonance imaging sequences has been a major obstacle. The goal of this study was to demonstrate the feasibility of a high-resolution and high-contrast targeting sequence for centromedian-parafascicular deep brain stimulation using a recently described magnetic resonance imaging sequence, three-dimensional edge-enhancing gradient echo. Methods The three-dimensional edge-enhancing gradient echo sequence was performed on a normal volunteer for a total of six acquisitions. Multi-image co-registration and averaging was performed by first co-registering each of the six scans and then averaging to produce an edge-enhancing gradient echo-multi-image co-registration and averaging scan. The averaging was also performed for two, three, four and five scans to assess the change in the signal-to-noise ratio and identify the ideal balance of image quality and scan time. Results The edge-enhancing gradient echo-multi-image co-registration and averaging scan allowed clear boundary delineation of the centromedian and parafascicular nuclei. The signal-to-noise ratio increased as a function of increasing scan number, but the added gain was small beyond four scans for the imaging parameters used in this study. Conclusions The recently described three-dimensional edge-enhancing gradient echo sequence provides an easily implementable approach, using widely available magnetic resonance imaging technology without complex post-processing techniques, to delineate centromedian and parafascicular nuclei for deep brain stimulation targeting.
- Subjects :
- Deep brain stimulation
Deep Brain Stimulation
medicine.medical_treatment
Thalamus
Co registration
Signal-To-Noise Ratio
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Effective treatment
Radiology, Nuclear Medicine and imaging
Physics
Epilepsy
Original Articles
General Medicine
Magnetic Resonance Imaging
Thalamic Nuclei
Brain stimulation
Centromedian nucleus
Neurology (clinical)
Parafascicular nucleus
Neuroscience
030217 neurology & neurosurgery
Gradient echo
Subjects
Details
- ISSN :
- 23851996 and 19714009
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- The Neuroradiology Journal
- Accession number :
- edsair.doi.dedup.....4269fd874a6ba248a4c11bbd9a03a1da