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Increased dietary NaCl potentiates the effects of elevated prorenin levels on blood pressure and organ disease
- Source :
- Campbell, D J, Karam, H, Bruneval, P, Mullins, J J & Menard, J 2010, ' Increased dietary NaCl potentiates the effects of elevated prorenin levels on blood pressure and organ disease ', Journal of Hypertension, vol. 28, no. 7, pp. 1429-1437 . https://doi.org/10.1097/HJH.0b013e3283391f13
- Publication Year :
- 2010
-
Abstract
- Background Rats with several 100-fold elevation of plasma prorenin levels due to liver-specific expression of a rat prorenin transgene have cardiac and aortic hypertrophy, renal lesions, and myocardial fibrosis. The effect of increased dietary NaCl on the phenotype of prorenin transgenic rats has not been examined.Methods and results We compared the effects of 0.3 and 2% dietary NaCl in wild-type and transgenic rats from 3 to 12 months of age. In comparison with wild-type rats, transgenic rats receiving 0.3% dietary NaCl had approximately 1000-fold elevation of prorenin, 1.5-fold to 2.5-fold elevation of renin concentration and activity, wildtype levels of angiotensin II, and were hypertensive with cardiac and aortic hypertrophy, and increased renal glomerular and tubulo-interstitial injury score. In wild-type rats, 2% dietary NaCl reduced angiotensin levels, produced a delayed increase in blood pressure, and caused cardiac hypertrophy and tubulo-interstitial injury. By contrast, 2% NaCl did not reduce angiotensin levels in transgenic rats, potentiated their hypertension, cardiac and aortic hypertrophy, and increased myocardial interstitial and perivascular fibrosis, without effect on glomerular or tubulointerstitial injury score.Conclusion Increased dietary NaCl had a greater impact on the phenotype of transgenic than wild-type rats that may have been due, in part, to their hypertension and their failure to suppress angiotensin levels, consequent to their elevated prorenin levels. J Hypertens 28: 1429-1437 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
- Subjects :
- Male
medicine.medical_specialty
Angiotensins
Cardiac fibrosis
Physiology
Blood Pressure
Cardiomegaly
Peptide hormone
Article
Muscle hypertrophy
Random Allocation
Fibrosis
Internal medicine
Renin
Renin–angiotensin system
Internal Medicine
Animals
Medicine
Sodium Chloride, Dietary
Retrospective Studies
Enzyme Precursors
business.industry
Angiotensin II
fungi
medicine.disease
Rats
Endocrinology
Blood pressure
Hypertension
Kidney Diseases
Myocardial fibrosis
Rats, Transgenic
business
Cardiology and Cardiovascular Medicine
Chymosin
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Campbell, D J, Karam, H, Bruneval, P, Mullins, J J & Menard, J 2010, ' Increased dietary NaCl potentiates the effects of elevated prorenin levels on blood pressure and organ disease ', Journal of Hypertension, vol. 28, no. 7, pp. 1429-1437 . https://doi.org/10.1097/HJH.0b013e3283391f13
- Accession number :
- edsair.doi.dedup.....4257bee02bd9ade09f2fa3dd0147ff08