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Antibody effector functions in malaria and other parasitic diseases: a few needles and many haystacks
- Source :
- Immunology & Cell Biology. 98:264-275
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Many parasitic infections stimulate antibody responses in their mammalian hosts. The ability of these antibodies to protect against disease varies markedly. Research has revealed that functional properties of antibodies determine their role in protection against parasites. Investigations of antibodies against Plasmodium spp. have demonstrated a variety of functional activities, ranging from invasion inhibition and parasite growth inhibition to antibody-dependent cellular phagocytosis and antibody-dependent cellular cytotoxicity. These activities have been demonstrated with a large variety of parasite molecules at multiple life cycle stages, highlighting the importance of functional antibody responses in malaria. Other parasitic infections have not yet been investigated in similar detail, but these mechanisms are likely to operate in nonmalarial parasitic infections as well. In this report, we review data on the role of functional antibody responses in protection from parasitic infections, highlighting discoveries in malaria, a parasite for which our knowledge base is the most advanced.
- Subjects :
- 0301 basic medicine
Plasmodium
Erythrocytes
Schizonts
Immunology
Antibodies, Protozoan
Receptors, Fc
Disease
Antibodies
03 medical and health sciences
0302 clinical medicine
Phagocytosis
Immunity
Parasitic Diseases
medicine
Animals
Humans
Immunology and Allergy
Parasite hosting
Parasites
biology
Transmission (medicine)
Antibody-Dependent Cell Cytotoxicity
Complement System Proteins
Cell Biology
biology.organism_classification
medicine.disease
Malaria
030104 developmental biology
Immunization
Sporozoites
biology.protein
Antibody
030215 immunology
Subjects
Details
- ISSN :
- 14401711 and 08189641
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- Immunology & Cell Biology
- Accession number :
- edsair.doi.dedup.....4240a848ba541627711deb29904d2505