Periodontitis is associated with an increased hazard of mortality in a longitudinal cohort study over 50 years

To evaluate the association between periodontal disease and all-cause mortality in a longitudinal cohort study over 50 years.Participants (N = 1156) in the Veterans Affairs Dental Longitudinal Study, aged 25-85 years at enrollment in 1968, received comprehensive medical and oral exams approximately every 3 years through 2007. Periodontal status was defined using person-level, mean whole-mouth radiographic alveolar bone loss (ABL) scores using a five-point Schei ruler, each unit representing 20% increments of ABL. Time-varying Cox regression models estimated hazard ratios (HRs) for the association between continuous and categorical ABL and mortality, adjusting for covariates.Each one-unit increase in mean ABL score was associated with a 14% increase in the hazard of mortality (adjusted HR = 1.14, 95% confidence interval [CI] 1.02, 1.27). When assessed categorically, HRs for average scores of 2 to3 and 3 to ≤5 showed increasing associations with hazard of mortality, relative to 0 to1 (adjusted HR = 1.17, 95% CI 0.94, 1.46; and HR = 1.65, 95% CI 0.94, 2.85, respectively). By contrast, we observed null associations for average scores of 1 to2 relative to 0 to1 (adjusted HR = 1.00, 95% CI 0.86, 1.17).Time-varying periodontal status assessed using radiographic ABL was positively associated with all-cause mortality even after confounder adjustment.