New imidazopyridopyrimidine:naphthyridine base-pairing motif, ImNN:NaOO, consisting of a DAAD:ADDA hydrogen bonding pattern, markedly stabilize DNA duplexes

Authors :: Akira Matsuda
Kazuyuki Kuramoto
Noriaki Minakawa
Yusaku Kikuchi
Yasuyuki Hirama
Noriko Tarashima
Source :: Chemical Communications. 47:10818
Publication Year :: 2011
Publisher :: Royal Society of Chemistry (RSC), 2011.
Abstract: The new imidazopyridopyrimidine:naphthyridine base-pairing motifs, ImO(O):NaN(N) and ImN(N):NaO(O), were designed. Among the base pairs examined, DNA duplexes containing ImN(N):NaO(O) pair(s) consisting of a DAAD:ADDA hydrogen bonding pattern (D = donor, A = acceptor) were markedly stabilized thermally and thermodynamically.

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