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Exceptional in vivo catabolism of neurodegeneration-related aggregates
- Source :
- Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-12 (2018), Acta Neuropathologica Communications
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- Neurodegenerative diseases are linked to a systemic enzyme resistance of toxic aggregated molecules and their pathological consequences. This paper presents a unique phenomenon that Philodina acuticornis, a bdelloid rotifer, is able to catabolize different types of neurotoxic peptide and protein aggregates (such as beta-amyloids /Aβ/, alpha-synuclein, and prion) without suffering any damage. P. acuticornis is capable of using these aggregates as an exclusive energy source (i.e., as ‘food’, identified in the digestive system and body) in a hermetically isolated microdrop environment, increasing their survival. As regards Aβ1–42, five other bdelloid rotifer species were also found to be able to perform this phenomenon. Based on our experiments, the Aβ1–42-treated bdelloid rotifers demonstrate significantly increased survival (e.g. mean lifespan = 51 ± 2.71 days) compared to their untreated controls (e.g. mean lifespan = 14 ± 2.29 days), with similar improvements in a variety of phenotypic characteristics. To our knowledge, no other animal species have so far been reported to have a similar capability. For all other microscopic species tested, including monogonant rotifers and non-rotifers, the treatment with Aβ1–42 aggregates proved to be either toxic or simply ineffective. This paper describes and proves the existence of an unprecedented in vivo catabolic capability of neurotoxic aggregates by bdelloid rotifers, with special focus on P. acuticornis. Our results may provide the basis for a new preclinical perspective on therapeutic research in human neurodegenerative diseases.
- Subjects :
- 0301 basic medicine
Philodina acuticornis
Rotifera
Rotifer
Kaplan-Meier Estimate
Protein aggregation
Beta-amyloid
Klinikai orvostudományok
Protein Aggregation, Pathological
lcsh:RC346-429
Pathology and Forensic Medicine
Alpha-synuclein
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Species Specificity
In vivo
Cell Line, Tumor
medicine
Tardigrada
Animals
Humans
Lobosea
Caenorhabditis elegans
lcsh:Neurology. Diseases of the nervous system
Amyloid beta-Peptides
biology
Lifespan
Catabolism
Research
Neurodegeneration
Neurodegenerative Diseases
Orvostudományok
medicine.disease
biology.organism_classification
030104 developmental biology
Metabolism
Biochemistry
chemistry
Platyhelminths
Oligohymenophorea
Prion
Neurology (clinical)
Energy source
030217 neurology & neurosurgery
Bdelloid rotifer
Subjects
Details
- Language :
- English
- ISSN :
- 20515960
- Volume :
- 6
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Acta Neuropathologica Communications
- Accession number :
- edsair.doi.dedup.....420e405addef95ec870a7e82eb7fa1ed